DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SYT1 and Syt1

DIOPT Version :9

Sequence 1:	NP_001129277.1	Gene:	SYT1 / 6857	HGNCID:	11509	Length:	422	Species:	Homo sapiens
Sequence 2:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	252/443 - (56%)
Similarity:	306/443 - (69%)	Gaps:	32/443 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     2 VSESHH-----------EALA-------------APPVTTVATVLPSNATEPASPGEGKEDAFSK 42
            :.|:||           |.||             ....|..||.....:|..|.|...|.:...:
  Fly    34 LEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGE 98

Human    43 LKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDV 107
            :..:.:.|  :..||.|.::||.|:..|:|....| .|.:...||:..|.||   ||..::||.|
  Fly    99 VVTEVIAE--RTGLPTWGVVAIIILVFLVVFGIIF-FCVRRFLKKRRTKDGK---GKKGVDMKSV 157

Human   108 KDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPAL 172
            :.||...|::...|.:..|...:..::|:.:.|:|||:|.:.|:|||.:|.|.|.:|||.|||||
  Fly   158 QLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPAL 222

Human   173 DMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFDRFS 236
            ||||||||||||:||||||||||||||||||:|||||.|||| :||::...||||.|::||||||
  Fly   223 DMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFS 287

Human   237 KHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKE-EQEKLGDICFSLRYVPTAGKLTVVILEAKNL 300
            |||.|||.|||:.|:|.....||||||.|.|.| .||||||||||||||||||||||||||||||
  Fly   288 KHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNL 352

Human   301 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDY 365
            |||||||||||||||.:||||||||||||:|||.|||||||||||||||||||||:.:||||:||
  Fly   353 KKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDY 417

Human   366 DKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAML 418
            |:||.::.||:..:|...||.||||||||||:|||||||||||:..||.|.:|
  Fly   418 DRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEIL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYT1	NP_001129277.1	Syt1_N	6..113	CDD:409248	35/130 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		5/28 (18%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		185/247 (75%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	87/122 (71%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	112/134 (84%)
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	24/104 (23%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	88/123 (72%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	112/134 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3696
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4122
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1535
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm41141
orthoMCL	1	0.900	-	-		OOG6_106413
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4219
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870