Protein Alignment SYT1 and Syt12

DIOPT Version :9

• Sequence 1: NP_001129277.1
• Gene: SYT1 / 6857
• HGNCID: 11509
• Length: 422
• Species: Homo sapiens
• Sequence 2: NP_001259513.1
• Gene: Syt12 / 32290
• FlyBaseID: FBgn0261085
• Length: 787
• Species: Drosophila melanogaster
• Alignment Length: 338
• Identity: 96/338 - (28%)
• Similarity: 158/338 - (46%)
• Gaps: 48/338 - (14%)

Human    93 GKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYD---- 153
            |...|..:.||::..........|..|..|..:...|           :..|.|...|:||
  Fly   443 GSVPGSMDGINLERAISCDSVTSDSTLFLDQLDQPYT-----------QITGYLCVGLNYDQMSI 496

Human   154 -FQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPY 217
             .:..:|.|.:::|..|.......:.|.:|:::|:||.....:|||.:.||.|.:||.|.|.: :
  Fly   497 SNEGMELTVSVLEAKGLICPFSVESLDTFVRIYLVPDHPGAMQTKVVKGTLTPSYNESFDFWL-H 560

Human   218 SELGGKTLVMAVYDFDRFSKHDIIGEFKV-------PMNTVDFGHVTEEWRDLQSAEKEEQEKLG 275
            ......:|...:|  .....|.:|||.::       |:.|         |..|..:.| ...:.|
  Fly   561 KRQARHSLWFHLY--HNGPAHTLIGEAEMEIGEMPRPITT---------WIPLSDSRK-CNARWG 613

Human   276 DICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDP---------YVKIHLMQNGKRLKKKKTTI 331
            ::.|||.|:|||.:||:|:::|:|| |:| |....|         :||::||...:::.||:|::
  Fly   614 ELMFSLSYLPTAERLTIVVVKARNL-KLD-GEQPAPESAETVHSVFVKVYLMDKDRKVLKKRTSL 676

Human   332 KKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLA 396
            |:...:|.:|||..|.||...:...|:.|||......|.. .:|.:..|..:.|..||||..||:
  Fly   677 KRKDRSPIFNESMIFSVPPPSLTTTQLRVTVFGVTTSGVT-PLGHIVAGSCAVGKGLRHWHQMLS 740

Human   397 NPRRPIAQWHTLQ 409
            :.|:|:|.||.|:
  Fly   741 SLRKPVAMWHVLR 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYT1	NP_001129277.1	Syt1_N	6..113	CDD:409248	4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..142		4/28 (14%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		75/266 (28%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	34/133 (26%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	52/143 (36%)
Syt12	NP_001259513.1	C2	503..602	CDD:278593	28/110 (25%)
		C2B_Synaptotagmin-12	612..753	CDD:176051	52/143 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820