DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SYT1 and Rph

DIOPT Version :9

Sequence 1:	NP_001129277.1	Gene:	SYT1 / 6857	HGNCID:	11509	Length:	422	Species:	Homo sapiens
Sequence 2:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster

Alignment Length:	359	Identity:	107/359 - (29%)
Similarity:	169/359 - (47%)	Gaps:	40/359 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    85 FKKKNKKKGKEKGGKNAINMKDVK------DLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEK- 142
            |.::..::..|....::::|..::      ..|......::.|.........|..:.:.:.::.
  Fly   278 FNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSGNSQTQSQYQQHQ 342

Human   143 -----------LGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKV-FLLPDKKKKF- 194
                       ||.|:.::.|....:.|...:::|.:|||:|..|.:|||.|: .:.|:...|:
  Fly   343 QQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYCKLNIITPEAHTKYT 407

Human   195 ---ETKVHRKTLNPVFNEQFTF-KVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
               .||...||.||.|||...| .|...|||...:.:|::|.|::. ||.:|..||.::||   |
  Fly   408 RWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFDDDKYG-HDFLGAAKVCLSTV---H 468

Human   256 VTEEWR--------DLQS--AEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSD 310
            .|.::|        |..|  ||..:....|.:..||.|......|.|.:.:..||..||..|.||
  Fly   469 STSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSD 533

Human   311 PYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGK-NDAI 374
            |:|||.|..:..:.||.||::|..||||.|||.|.||.....:.|..:::||.|.| :|| ||.:
  Fly   534 PFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKD-LGKSNDFL 597

Human   375 GKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTL 408
            |.:.:|..|.|..|:.|.|.:..|.....:||.|
  Fly   598 GSLQLGAQSKGERLQQWLDCIRLPDHFHEKWHCL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYT1	NP_001129277.1	Syt1_N	6..113	CDD:409248	4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		2/28 (7%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		92/274 (34%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	45/135 (33%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	53/136 (39%)
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	44/126 (35%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	51/132 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910