Protein Alignment SYN1 and Syn

DIOPT Version :10

• Sequence 1: NP_008881.2
• Gene: SYN1 / 6853
• HGNCID: 11494
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_731459.2
• Gene: Syn / 41247
• FlyBaseID: FBgn0004575
• Length: 1041
• Species: Drosophila melanogaster
• Alignment Length: 834
• Identity: 272/834 - (32%)
• Similarity: 386/834 - (46%)
• Gaps: 203/834 - (24%)

Human     1 MNYLRRRLSDSNFMANL----PNGYMTDLQRP------QPP--------PPPPGAHSP-GATP-- 44
            :|:|:||.|..:..:.:    ||. :....||      :||        ||||....| ||.|
  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNS-LPPAARPIQDQPTKPPVAGGPPNMPPPPAPGQPAGAAPEL 77

Human    45 ----GPGTATAERSSGVAPAASPAAP-SPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGG-S 103
                |.|...|  ::..||....:|| ||..|.     .||...|:..|.||....:..:|.. .
  Fly    78 SLSFGAGKTPA--TAAPAPPRGVSAPTSPAKSR-----ESLLQRVQSLTGAARDQGASILGAAVQ 135

Human   104 GGAGRGGAASR----VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVD 164
            ....|..|.|:    .|||:|:.:|||:|||:|:::||:.||:||||||.|:.:|:.|:.|..|.
  Fly   136 SATQRAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVT 200

Human   165 MEVLRNGVKVVRSLKPDFVLIRQHAFSMARNG--DYRSLVIGLQYAGIPSVNSLHSVYNFCDKPW 227
            |...|:|.:|.||.:||||||||    ..|:|  ||||.::||:|.|:||:|||||:|.|.||||
  Fly   201 MAAYRSGTRVARSFRPDFVLIRQ----PPRDGSSDYRSTILGLKYGGVPSINSLHSIYQFQDKPW 261

Human   228 VFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIA 292
            ||:.:::|.::||.:.||||:|||:||.:::...|.:|.|:|.||.|.|:...:::||...||.|
  Fly   262 VFSHLLQLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAA 326

Human   293 SVVA----LTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRY 353
            .:|:    .:..|.|.||:||||:.|.:||||.||||:||.|::||||||.||||||||.::::|
  Fly   327 GLVSGAGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKY 391

Human   354 KLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQAL 418
            |.|||..||:|||:::|.:..:..||||::||....|:..||||.|:||::.|.:||..:| |.:
  Fly   392 KSWVDEISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRM-QNV 455

Human   419 PRQRQRDASPGR-------GSHGQTPS-PGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQ 475
            .|.......||:       .|..::|: .|..|    |...||||    ||.|.||||   |.|:
  Fly   456 CRPSMAQTGPGKLPSRSSVSSRAESPTDEGVAP----TPPLPAGP----RPAPMGGPP---PIPE 509

Human   476 RQGP---------------PLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPP 525
            |..|               .:.:.|...|...:.|:...:.:.....:.|..|.    |.|..|.
  Fly   510 RTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGVRRDSQTSQSSTISSSVSR----AGQRPPQ 570

Human   526 TQ------------------------------------------GQGRQSRPVAGGPGA------ 542
            ||                                          |.|..|.|.:.|||:
  Fly   571 TQNSVVEDAEDTMKNLRKTFAGIFGDMXEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSF 635

Human   543 ---------------------PPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPG--- 583
                                 .|:..|||.|:....|..|:::...|.|.........|..|
  Fly   636 LGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQP 700

Human   584 -----GQQRQGPPQKPPGPAGPT-----------RQASQAGPVPRTGPPTTQQPRPSGPGPAGRP 632
                 .|:|..|..|.|..:|..           ..:|.:..:.|.|......|.|:||.|
  Fly   701 VTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPP---- 761

Human   633 KPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 686
                        |||....|.|   ...|.|....|:|:        .|||:|:
  Fly   762 ------------PPPTNVTAVG---SNANSSSGYRNSFS--------SSLSKDK 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYN1	NP_008881.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		29/97 (30%)
		A	1..28		7/30 (23%)
		Synapsin_N	1..27	CDD:463155	7/29 (24%)
		B, linker	29..112		28/99 (28%)
		C, actin-binding and synaptic-vesicle binding	113..420		156/316 (49%)
		Synapsin	115..212	CDD:460438	50/98 (51%)
		CPSase_L_D2	214..416	CDD:473076	102/205 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..689		78/380 (21%)
		D, Pro-rich linker	421..655		68/344 (20%)
		PRK07764	<494..686	CDD:236090	52/279 (19%)
		E	656..705		8/31 (26%)
Syn	NP_731459.2	Synapsin	150..246	CDD:460438	50/99 (51%)
		CPSase_L_D2	248..452	CDD:473076	101/203 (50%)
		PHA03307	425..>700	CDD:223039	64/290 (22%)