Protein Alignment Itga2b and scb

DIOPT Version :10

• Sequence 1: NP_001413964.1
• Gene: Itga2b / 685269
• RGDID: 1596428
• Length: 1037
• Species: Rattus norvegicus
• Sequence 2: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Alignment Length: 1158
• Identity: 280/1158 - (24%)
• Similarity: 454/1158 - (39%)
• Gaps: 250/1158 - (21%)

  Rat    37 VKFSVYTGPNGSHFGFSVDFHKDSHGSVSIVVGAPRALNANQ-----EETGGVFLCPWKANNGTC 96
            :||.: .....|:||:::...:     .||:||||||.:..:     .|||.::.|  ...||.|
  Fly    41 LKFHI-NQTRSSYFGYTLVIRQ-----TSIIVGAPRAQSTLESQRTINETGAIYRC--SLTNGVC 97

  Rat    97 TSLLFDLRDET-RKLSLQTFQT-FKTGQGLGASV---LSWNDVIVACAP---------------- 140
            :..:.|.|... ...|..||.: .|..|.||.|:   ....|.::.|||
  Fly    98 SPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHLHGVC 162

  Rat   141 -WQHWNVLEKYDEAEKTPVGGCFVAELQSGGRAEYSPCRSNTMSSVYSQGFSGDKRYCEAGFSLA 204
             |.:       :....||.....::.|:............|..|..|..|        |.|.|..
  Fly   163 YWVN-------NTVASTPQHVTRISPLRLKSEQVKEEDNGNKASFFYIMG--------ELGLSAH 212

  Rat   205 VTQAG-ELVLGAPGGYFFLGLLVRV----PIENIISSYRPGTLLWHVSNQRFSYDSSNPVYF--- 261
            |.... :.::||||...:.|.::..    |::|..:|.|..:.....:.:....:...|.::
  Fly   213 VADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPE 277

  Rat   262 -----------HGYRGYSVAVGEFDGDLST-TEYIFGAPTWSWTLGAVEILDSYYQTLHRLH--- 311
                       ..|.||:|:.|.||....| ..|:..||..:...|...|.|...:::|:.|
  Fly   278 IPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFR 342

  Rat   312 GEQMASYFGHSVAVTDVNGDGRHDLLVGAPLY-MESRVDRKLAEVGRVYLFLQPKGL-----QAL 370
            |||...|||:||...|:||||:.|::|.||.: :|...|.     |.:|:|:. ||.     |.|
  Fly   343 GEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDN-----GAIYVFIN-KGFFNFERQIL 401

  Rat   371 SSPTLVLTGTQVYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQ 435
            .||      .:...|||:|::.|||:|.||||||||.||:   :|.|.|.|:||...||..:|||
  Fly   402 RSP------VETMARFGTALSRLGDINHDGYNDVAVGAPF---AGNGTVFIYLGSENGLRDQPSQ 457

  Rat   436 VLDSPF--PTGSG---FGFSLRGSVDIDDNGYPDLIVGAYGASKVAVYRAQPVVM--ATVQLMVQ 493
            .||:|.  |:..|   ||..|....|||.||:.|..:||..|..|.:|||.|||.  |||:...:
  Fly   458 RLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESR 522

  Rat   494 DSLNPTLKNCVLEQTKTPV-SCFNVQMCVGATGHNIPQKLHLKAELQLDLQKPRQARRVLLLASR 557
            : :.|       ||.|..: :|:.:..       ....||..:.||.:.:...:|.:||....::
  Fly   523 E-IKP-------EQEKVKITACYRLST-------TSTDKLVQEQELAIRIAMDKQLKRVKFTQTQ 572

  Rat   558 --QASLTLSLDLGGRNKPICHTIKAFLRDEADFRDKLSPIVLSLNVSLP---PEETGVAPAVVLH 617
              :.|..::.:.|.:    |...:..:|...  :|..:||.|.::..|.   |:.........:.
  Fly   573 TNEISFKVNANFGEQ----CRDFETQVRYSE--KDIFTPIDLEMHYELTKKVPDSEEFCETCAIV 631

  Rat   618 GVTHVQEQTRIIL---DCGEDNLCVPQLQLTATAGDSPLLIGADNVLELKVNASNDGEGAYEAEL 679
            ..|..:..|:.|:   .|..| :|...|||.:.......::|:.:.|.|....:|.||.||
  Fly   632 DPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAY---- 691

  Rat   680 AVHLPPGAHYIRAFSNVKGFERLVCTQKKEN---ESRLALCEL--GNPMKKDTRIGITMLVSVEI 739
               ||.        .||....||...|...|   ...:.:|:|  |.|:.|.....:|  :|.::
  Fly   692 ---LPQ--------FNVTSTSRLAFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSVT--ISFDV 743

  Rat   740 LEEAGDSVSFQLQIRSKN-SQNPNSEAVLLPVAVRAEAAVELRGNSFPASLVVAAEEVDKEQDGL 803
            .:.:|.|:....::.|.. .|||........:.::....::..|..       ...::|.|.
  Fly   744 SQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQ-------TNSQIDLEH--- 798

  Rat   804 DSWVSRVEHTYELHNNGPGTVNGLSLIIHLPGQSQPSDLLYILDVQPKGGLLCSTQPPPKLLKVD 868
            .|..:.:.:.||:.:|||..:..|::..::|...:.:....|:.:.....|........:||.:|
  Fly   799 YSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSID 863

  Rat   869 R-------------RLTTPSPSSIRR-----------------IHHDRDRREAS--PQGSKQTEQ 901
            .             .:||.....:.|                 :|...:..:.|  ...|...::
  Fly   864 LYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKR 928

  Rat   902 QDPVLVSCN---------------------GSAPCT---VVECELQEMVRGQRAMVTVQATLGLS 942
            :|...::.|                     |..|..   |..|...||....||.:.|......|
  Fly   929 RDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKS 993

  Rat   943 I-LRQR--------------PQEQFVLQSHAWFNVSSLPYSVPVVSLPSGQGLVQTHLLRALEER 992
            | |..|              |.|.||:.:.........|.|...    |....::.:::...:|.
  Fly   994 INLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSF----SINRRIEPNIISKHQET 1054

  Rat   993 DIPVWWVLVGVLGGLLLLTLLVLAMWKAGFFKRNRP----------PLEEEEE 1035
            .:|:|.::|.|:||||||:.:...::|.|||.|.:.          |:|.|.|
  Fly  1055 GLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPEAE 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Itga2b	NP_001413964.1	None
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/58 (31%)
		FG-GAP	350..388	CDD:460357	17/42 (40%)
		Int_alpha	409..459	CDD:214549	29/52 (56%)
		Int_alpha	473..>515	CDD:214549	19/41 (46%)
		Integrin_alpha2	509..829	CDD:462478	76/368 (21%)