Protein Alignment Atp8b2 and CG33298

DIOPT Version :10

• Sequence 1: XP_001062555.3
• Gene: Atp8b2 / 685152
• RGDID: 1597731
• Length: 1209
• Species: Rattus norvegicus
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1330
• Identity: 426/1330 - (32%)
• Similarity: 666/1330 - (50%)
• Gaps: 256/1330 - (19%)

  Rat    13 RAGAPPSWSQK---KPSWGTE-EERRARA----------NDREYNEKFQYASNCIKTSKYNILTF 63
            |..|||.|.:.   ..:.|.: |||..|.          ..:..:...|:..|.|:|:||.:|:|
  Fly   201 RTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSF 265

  Rat    64 LPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQ 128
            :|.||.|||..|||.||:|:::|..:|:||:......::|::.||.:|||||..:|..|..||.:
  Fly   266 IPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKR 330

  Rat   129 VNSRHSQVLINGVLQ---QEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETSELDGE 190
            :|:...:| .:|..:   :.:|..:.||||:.|.||:.|.||:|||.:|:|.|:|||:|.:||||
  Fly   331 INNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGE 394

  Rat   191 TNMKVRQAIPVTSELGDISQLAKFDGEVICEPPNNKLDKFSGAL-YWKGNKFPLSNQNMLLRGCV 254
            ||:|.|:.:....|:..|...:||...|..:.|..||.:|.||| :..|.:.|:|.:.:|||...
  Fly   395 TNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESR 459

  Rat   255 LRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEH 319
            |:||::..|:|::||.:||.|.|:...::||:.:::.||..|:|....|:.:.|:.|||..:|..
  Fly   460 LKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS 524

  Rat   320 EVGTRFQV-YLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMF 383
            .. |.|.| |||.::.  :|.......||:||:||..::|:||||::|:.::...:.|:.:..:|
  Fly   525 SF-THFPVPYLPPNKL--TANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLF 586

  Rat   384 CMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGE 448
            ..:.....|.|...:.|||||:::||:|||||||:|.|:|.:|.:||..|......|........
  Fly   587 DAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPG 651

  Rat   449 RPEPVDFSFNPLADKKFLFWDPSLLEAVKMGDPHT---HEFFRLLSLCHTVM------------- 497
            .|.|      ||.....|..|.:.|.......||.   .||..:|::|:||:
  Fly   652 APAP------PLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNAS 710

  Rat   498 ----------------------------------------------------------------- 497
                                                                             
  Fly   711 GIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVT 775

  Rat   498 ----------------------------------SEE-----KNE-------------------- 503
                                              ||.     ||:
  Fly   776 PSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKI 840

  Rat   504 -----------------------GELY--------YKAQSPDEGALVTAARNFGFVFRSRTPKTV 537
                                   |.:|        |:|:||||.|||.||.::.....:|:|..:
  Fly   841 TSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQI 905

  Rat   538 TVH--ELGTSITYQLLAILDFNNIRKRMSVIVRN-PEGKIRLYCKGADT----ILLDRLHPSTQE 595
            .|.  ..|.:..|::|.:|.|::.||.||::||. ...:|.||.||||:    :|:...|.|.:.
  Fly   906 LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG 970

  Rat   596 LLNSTTDH-LNEYAGDGLRTLVLAYKDLDEEYYEEWARRRLQASLAQDSREDRLASIYEEVESDM 659
            :|...|.. |:.||.:|||.||:|.:.|:...|.:|..|..:..::.::||.||...:.::||::
  Fly   971 ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNL 1035

  Rat   660 MLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHT 724
            .|||||.|||:||.|||||||.|..|.|.:|||||||.|||:||.||.|:.|..|
  Fly  1036 TLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM---------- 1090

  Rat   725 VLEVREELRKARKKMVDSSHAVGNGFTYQGNLSSSKLTSVL----EAVAGEYALVINGHSLAHAL 785
                  ||.:...:..|::....|  .|..::.:.|.||.|    .....:.|||::|.:|...|
  Fly  1091 ------ELIRLTARSRDAAETAIN--FYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFIL 1147

  Rat   786 E--ADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGV 848
            :  :.:.|.||..:..|.:|:|||.||||||.:|::||:.....||||||||||||||:.|.:||
  Fly  1148 DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGV 1212

  Rat   849 GISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCG 913
            |||||||:|||:|:|::..:|::|:||||.||.|.|.|:.:.:.||||||.||..:.||:..:||
  Fly  1213 GISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCG 1277

  Rat   914 FSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIA 978
            ||.|.:.||.::.|||:::||||.||:||:|:.|.|...::.|.||:.|:|.:.:...:|::.:.
  Fly  1278 FSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILL 1342

  Rat   979 QGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFI 1043
            ..:|.|:::||:....:||:  |.|     ...|..|:..|.:....|...::...||.::...|
  Fly  1343 DALYQSLVIFFVALCAYAES--DVG-----IWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSI 1400

  Rat  1044 WGSLAVY--FAILF---AMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTAVCIMPVVAF 1103
            ..||..:  |||::   .|:..|:...:...|....:|.:       ||.|:|:|.|.::|.:..
  Fly  1401 VLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPRLLL 1458

  Rat  1104 RFLRLSLKPDLSDTVRYTQLVRKKQKAQHR 1133
            ..:|:||.||.|     |:::.:.::.:.|
  Fly  1459 TTVRISLCPDDS-----TKVILQSKRERSR 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp8b2	XP_001062555.3	P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	380/1130 (34%)
		Cation_ATPase_C	929..1104	CDD:376368	49/179 (27%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	380/1130 (34%)