DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kcnc4 and Shawl

DIOPT Version :9

Sequence 1:	XP_038959057.1	Gene:	Kcnc4 / 684516	RGDID:	1589169	Length:	663	Species:	Rattus norvegicus
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	251/735 - (34%)
Similarity:	336/735 - (45%)	Gaps:	198/735 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat    33 EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGCEFFF 97
            :...:||:||.|.|:|||::||:.:|.|||:.|.:......|..:                |:||
  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLN----------------EYFF 50

  Rat    98 DRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIF 162
            |||||||..:||||||||||.|.|||||||||||.|||:|...||||||.||..|||.:..|.|.
  Fly    51 DRHPGVFTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAIL 115

  Rat   163 ESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQ---PRMWALFEDPYSSR 224
            :..          |...:...|..:.||    .|......:|....||   |::||:|::|.||.
  Fly   116 DKL----------DIENEKPTEEQIARL----FGFEEALSNGELNCWQRIKPKIWAMFDEPSSST 166

  Rat   225 AARVVAFASLFFILVSITTFCLETHEAFNID---------------------------------- 255
            .|::||..|:|||.||:.:|||:||..|.:|
  Fly   167 GAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQ 231

  Rat   256 -------RNVTEIHRVGNITSV---RFRREVETEPILT--------------------------- 283
                   .::....||.|.||.   .|....:..||.|
  Fly   232 HSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKIL 296

  Rat   284 ----------------------YIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPF 326
                                  |:|.||.:||.:|.::|::..|:...|:|:.:|||||.|.|.|
  Fly   297 GHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSF 361

  Rat   327 YLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLAL 391
            |.:|      .:...:..|.|.....|||:|:||||||..|||:|.||.:||..|..||:.||.|
  Fly   362 YTDV------MQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVL 420

  Rat   392 GVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGAL 456
            |::.||::.||||::       :.|....||:||:|.|||:|||||:||||:.|||:.||.||||
  Fly   421 GIVFFASLAYYAEKL-------QDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGAL 478

  Rat   457 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIYCKSEETSP-RDST 520
            ||||||||||:||||||:||.|:||...|:.||||||::.:|    :|.| ..|.|.|:| |..|
  Fly   479 CALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP----VEQP-RRKREPTAPHRGRT 538

  Rat   521 YSDTSPPAREEGMVERKRADSKQNGDANAVLSDEEGAGLTQPLASAPTPEERRALRRSGTRDRNK 585
            .:....|....|:|                      ||...|:.:........|:..|..
  Fly   539 NAIKQTPPTGPGLV----------------------AGGVVPVGAGGPGLGGHAVGHSAA----- 576

  Rat   586 KAAACFLLSAGDYACADGSVRKGCEKSRSLNNIAGAAGTSLGLSP---------LASRYSSPYPP 641
                    .|..:..|.|..:.|......:|.|        ||.|         :|...:.|.|.
  Fly   577 --------GAPMFKDAFGGAKIGTVNVNGVNVI--------GLHPAQRTTTTMAMAMNEADPTPM 625

  Rat   642 RKLLLSHPFHPLTSPPPGHS 661
            ..|....|....| |.|.||
  Fly   626 SALTYQVPMLQPT-PTPAHS 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnc4	XP_038959057.1	Potassium_chann	1..29	CDD:402836
		BTB_KCNC2_4	35..159	CDD:349722	64/123 (52%)
		Ion_trans	226..484	CDD:395416	127/350 (36%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	57/107 (53%)
		BTB_2	7..97	CDD:280393	55/105 (52%)
		Ion_trans	307..506	CDD:278921	102/211 (48%)
		Ion_trans_2	<449..499	CDD:285168	39/49 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	255	1.000	Domainoid score	I1967
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1505
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.160