DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik3 and par-1

DIOPT Version :9

Sequence 1:NP_001258145.2 Gene:Sik3 / 684112 RGDID:1593938 Length:1369 Species:Rattus norvegicus
Sequence 2:NP_995894.2 Gene:par-1 / 2768852 FlyBaseID:FBgn0260934 Length:1170 Species:Drosophila melanogaster


Alignment Length:1032 Identity:315/1032 - (30%)
Similarity:453/1032 - (43%) Gaps:253/1032 - (24%)


- Green bases have known domain annotations that are detailed below.


  Rat    16 GAGGAGPAGR-LLPPPAAGPPAAPAAVPPAACPP----RPTAPASRGSMAARIGYYEIDRTIGKG 75
            |:|.|....: :|...:|.|.|.......|...|    |.:||....:....||.|::.:|||||
  Fly   198 GSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKG 262

  Rat    76 NFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYL 140
            |||.||.|.||.|..:|||||||||||:..:|:|:||||:|||||.||:|::|:||:|||:.:||
  Fly   263 NFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYL 327

  Rat   141 VTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 205
            :.|||||||:||:||.||||.|||||.||:|||:||.:||.:.|:||||||||||||:.||||||
  Fly   328 IMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIA 392

  Rat   206 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 270
            ||||||.||||..|.|:||||||||||||:||:||||:||:|||||:||.||.|:||||||||:.
  Fly   393 DFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRE 457

  Rat   271 LRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHRWMKLGDADPNFERLIAECQQ 335
            ||.|||.||:||||:|||:||:|:|..|||:|.||.|:|.|...:||.:|..:...:..|.....
  Fly   458 LRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKAD 522

  Rat   336 LKEERQAEPLNDEVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKNKTLRPGALPST 400
            |     |:|...|.|:|   ||.::.....||....||...|.|.||            |...:.
  Fly   523 L-----ADPKRIEALVA---MGYNRSEIEASLSQVRYDDVFATYLLL------------GRKSTD 567

  Rat   401 PQAMTFQAPVNIQAEQTGTAMNISVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALVRYLS- 464
            |::         ...::|:::::           ..|...|...|..|...:.|:...:.|.:| 
  Fly   568 PES---------DGSRSGSSLSL-----------RNISGNDAGANAGSASVQSPTHRGVHRSISA 612

  Rat   465 -----MRRHTVGVADPRTEVMDEMQKLLPGFPGANPQTPFLQVAPNMNFMHNLLPMQSLQPTGQL 524
                 .||.:.||.......   ......|..||        |.|:.|:                
  Fly   613 SSTKPSRRASSGVGPTNAAA---TVAAATGAVGA--------VNPSNNY---------------- 650

  Rat   525 EYKEQSLLQPPTLQLLNGMGPLGRRASDG----------GANIQLHAQQLLKRPRGPSP-----L 574
                            |..|....|||.|          .|.|:.:..:|..:.:.|:.     |
  Fly   651 ----------------NAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKML 699

  Rat   575 VTM-----TPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTL----AMTSPTAEIPPD---L 627
            .|.     :||.|. |....:.::|..........:..||.  ||    :.|..|..||.:   .
  Fly   700 TTADTTLNSPAKPR-TATKYDPTNGNRTVSGTSGIIPRRST--TLYEKTSSTEKTNVIPAETNLF 761

  Rat   628 QRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLERMGN 692
            .|.....:.:|....|..||.  |||:....|    ..|.:....:| |.:......:|..||..
  Fly   762 DRLRMASAVKSSRHFPRNVPS--RSTFHSGQT----RARNNTALEYS-GTSGASGDSSHPGRMSF 819

  Rat   693 SSSIK-------------------QLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQH---- 734
            .|.:.                   :.....:....:...|:.::..|...|.:..|:|.:.    
  Fly   820 FSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLW 884

  Rat   735 --------HQILQQQIQDSICPPQPSPPLQAACENQPTLLTHQLQRLRIQPSSPPPNHPSNHL-- 789
                    ..::|.:|:  :|             ..|.|..:.::..||..:|....:.::.:  
  Fly   885 CVHGDPNTDSLVQWEIE--VC-------------KLPRLSLNGVRFKRISGTSIGFKNIASRIAF 934

  Rat   790 -----FRQPSNSPPPVSSAMISSHGATSPSQFQGLPSHGAIFQQQPENCSPPPS--------VAL 841
                 ..|.:|.    .:|..::...|.|:.           .....||..|.:        ::|
  Fly   935 DLKLXLNQTNNE----GNAAATASRPTDPTD-----------TMTTTNCRRPSNDSTSRLSELSL 984

  Rat   842 TCLGL--QQASQSQPVTIQLQEPVDMLSNMAGTTAGSAGRGIPISPSASQIQMQHRTSLMAPFGY 904
            .|..|  ||.||        :.....||     |.||.             ..:...||::.|..
  Fly   985 LCRSLTSQQGSQ--------RRKKSRLS-----TGGSE-------------DQKKSNSLLSAFQM 1023

  Rat   905 GHRPLSKQLSADSAE------------AHSLSMNRFSPANYDQAHLHPHLFSEQSRG 949
             :.|.|.:.:..|:|            .||:.:..|:    |.:.::| :..|.:.|
  Fly  1024 -YSPFSSKENMQSSEEVEDLHVIDTQPGHSVDVPLFA----DFSPINP-IMEEDAEG 1074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_001258145.2 STKc_SIK 65..317 CDD:270973 173/251 (69%)
UBA_like_SF 346..390 CDD:419673 13/43 (30%)
par-1NP_995894.2 STKc_MARK 252..504 CDD:270974 173/251 (69%)
S_TKc 253..504 CDD:214567 173/250 (69%)
UBA_MARK_Par1 525..563 CDD:270522 14/52 (27%)
MARK1-3_C 839..936 CDD:213381 13/111 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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