DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SUV39H1 and suv39h1b

DIOPT Version :9

Sequence 1:	NP_001269095.1	Gene:	SUV39H1 / 6839	HGNCID:	11479	Length:	423	Species:	Homo sapiens
Sequence 2:	NP_001119954.1	Gene:	suv39h1b / 326906	ZFINID:	ZDB-GENE-030131-5105	Length:	421	Species:	Danio rerio

Alignment Length:	413	Identity:	284/413 - (68%)
Similarity:	344/413 - (83%)	Gaps:	9/413 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    19 CSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKK--IRE------QEYYLVKW 75
            |.|.|.::..||:.:||...:.|..||||:.||.|:|||||||||:  |.:      ||.|||||
Zfish    10 CRVACIATTEQLEVVCRDEGVVCEELGISRNNLCDYEVEYLCDYKRKVITDGKRQTVQELYLVKW 74

Human    76 RGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALR 140
            :|||:|.:|||||:||:||.:|.||.:||..|:.|::.|| .||.|||:...:|.|:||.|:.|:
Zfish    75 KGYPESRNTWEPRRNLRCVNLLSQFWEDLNAEMQRQNKRS-APRRLDPATVTHLTQRAKLRQTLK 138

Human   141 RWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGC 205
            :||..||:..:|.|.|:|.|:|||:|||::|.|||:|:||:||.||:|:|||||.|||.:|..||
Zfish   139 QWETHLNSLGTHKGYISVRNQVDLEGPPKSFTYINDYKVGDGILLNEVSVGCECTDCLASPVEGC 203

Human   206 CPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVR 270
            |.|||.||||||:.||||:|.||||||||.|||||.||.|||||:||||.|||||||:|||||||
Zfish   204 CAGASQHKFAYNELGQVRIRPGLPIYECNKRCRCGPDCSNRVVQRGIRYSLCIFRTDNGRGWGVR 268

Human   271 TLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNH 335
            |:|:||||:|||||||||||:|||||||.:||::|||||||||||:|.||||||:||||||||||
Zfish   269 TMERIRKNTFVMEYVGEIITTEEAERRGHVYDKEGATYLFDLDYVDDEYTVDAAHYGNISHFVNH 333

Human   336 SCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLP 400
            |||||||||||||||||||||||||||||.|:|||||||||||::||||.|||:||:|||:.|||
Zfish   334 SCDPNLQVYNVFIDNLDERLPRIAFFATRGIKAGEELTFDYNMKIDPVDAESTKMDTNFGVMGLP 398

Human   401 GSPKKRVRIECKCGTESCRKYLF 423
            ||||||:|:|||||..:||||||
Zfish   399 GSPKKRMRVECKCGVATCRKYLF 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SUV39H1	NP_001269095.1	CD_SUV39H1_like	54..102	CDD:349289	33/55 (60%)
SUV39H1	NP_001269095.1	SET_SUV39H1	169..423	CDD:380923	202/253 (80%)
suv39h1b	NP_001119954.1	Chromo	46..101	CDD:278797	33/54 (61%)
		Pre-SET	146..244	CDD:282838	64/97 (66%)
		SET	<181..421	CDD:225491	194/239 (81%)
		SET	252..375	CDD:214614	107/122 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I11709
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2388
Inparanoid	1	1.050	615	1.000	Inparanoid score	I5096
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60038
OrthoDB	1	1.010	-	-		D177171at7742
OrthoFinder	1	1.000	-	-		FOG0001837
OrthoInspector	1	1.000	-	-		oto43114
orthoMCL	1	0.900	-	-		OOG6_100876
Panther	1	1.100	-	-	LDO	PTHR46223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X219
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.370