Protein Alignment ABCC8 and MRP

DIOPT Version :9

• Sequence 1: XP_016873686.1
• Gene: ABCC8 / 6833
• HGNCID: 59
• Length: 1604
• Species: Homo sapiens
• Sequence 2: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 1547
• Identity: 493/1547 - (31%)
• Similarity: 760/1547 - (49%)
• Gaps: 275/1547 - (17%)

Human   147 FITKTIKFVKFLDHAIGFSQLRFCLTGLLVILY----GMLLLVEVNVIRVRRYIFFKTPREVK-- 205
            |..:..:||.|.        :.|..|.:::||.    ||                   ||:.|
  Fly   181 FSWEEYQFVSFF--------IFFTFTSIMLILNCFADGM-------------------PRQTKYQ 218

Human   206 -PPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPI------DLRAIGKLPIAMRALTNY 263
             ...::.:|...|       ||:.||.|.:......::.|:      |||........|....::
  Fly   219 RGENEIPELSASF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHH 276

Human   264 QRLCEAFDAQVRKDIQG---------------------------TQGARAIWQALSHAFGRRLVL 301
                  ::..|||:.:.                           .:|..:|...:..:||...:.
  Fly   277 ------WNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLF 335

Human   302 SSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQ----EFLANAYVLAVLL 362
            .:..::..|.|.||                   ||:...|.:.||.:|    |:....|  ||||
  Fly   336 GALMKLFTDTLTFA-------------------QPQVLSLIISFVEAQDAEPEWKGILY--AVLL 379

Human   363 FLALLLQRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTN 426
            |: |...:||:...|:..: ..|:.:|.|:...||.|.:.:  ||.:..|.|.|:|.||:|:|..
  Fly   380 FV-LAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQ 441

Human   427 QLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEY 491
            :.|........:|:.|:||.:.:..|:..||.|.|.|.||:|:|.||...:|:::...|...::|
  Fly   442 RFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKY 506

Human   492 SNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVL 556
            .:||:|..||:|.|||:|||||||..|..:|...|.||:.:||:.|...:.:.|:.:..|....|
  Fly   507 KDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSL 571

Human   557 ITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIRE 621
            :||..:|...:....|......|::||.::..||.:|..:.....:..|||.::::||:|.|:
  Fly   572 VTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEEL-- 634

Human   622 EQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNRKRPAREDCRGLTGPLQ 686
                  :|.               ..||.|        :.|.|:.:.|
  Fly   635 ------DPN---------------SVLHDS--------SKPHPMSIEN----------------- 653

Human   687 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGE 751
                               |.|:| .|.| ||.||.|.:.:|.|..:||.||.||||::.|.|||
  Fly   654 -------------------GEFSW-GDEI-TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGE 697

Human   752 MQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPF 816
            |:|::|.|                           ...|.:||..|:.|:.||||.:||:|...:
  Fly   698 MEKLAGVV---------------------------NTVGKLAYVPQQAWIQNATVRDNILFGQTY 735

Human   817 NKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSA 881
            :::||..||:||:|:.|||||..||.|:|||:||||||||:||||:|||:|..|::..||||.||
  Fly   736 DRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSA 800

Human   882 LDIHLSDHLMQ-----AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQR 941
            :|.|:..|:.:     .|||.     :::.|||||.:.:||..|.|..:|.|.|...||.....:
  Fly   801 VDAHVGKHIFEEVIGPKGILA-----RKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVK 860

Human   942 SECQ----LFEHWKTLMNRQDQELEK---------------ETVTERKATEPPQGLSRAMS--SR 985
            ::..    :.:|.:. .|.:::||.:               .||.:.......:.||.::|  |.
  Fly   861 NKGAFADFIIQHLQE-GNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSA 924

Human   986 DGLL------------QDEEEEEEEAAESEEDDNLSSML-----HQRAEIPWRACAKYLSSAGIL 1033
            |.|:            ||..:....||..::...:...|     .|...:.:.....|:.|.||.
  Fly   925 DSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIF 989

Human  1034 LLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGI 1098
            |....:....:.....:..:.||.:|.:              .|....|..:..|...|..:.|.
  Fly   990 LSVATLVLNFVFQAFQIGSNLWLTQWAN--------------DQNVANDTGLRDMYLGVYGAFGF 1040

Human  1099 ---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPM-RFFETTPLGSILNRFSSDCNTIDQHIP 1159
               ||.....|.|...|.:.||.:|..||..||...: |||:.||:|.:||.||.|.:.:|:.:|
  Fly  1041 GQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELP 1105

Human  1160 STLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLS 1224
            :|::.......:.::.:.|||..||:||..::|:|.:.||.|:::...||.|.:|:..::.|:.|
  Fly  1106 ATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYS 1170

Human  1225 HFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTS 1289
            ||:|||.|.:||||:....||.::.....|.|.:.......|||||.:|:|.:|..::|.|::.:
  Fly  1171 HFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFA 1235

Human  1290 ISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAP 1354
            :   |..:.:.|||||.::|||.|:..|||:||..:|:|..:.:|:||....:|:.|:...|...
  Fly  1236 V---LGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQD 1297

Human  1355 SLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVD 1419
            ...|||||.:|:::.||..|||...|..||:.|:..|..|:|:||.||||:||||.:||.||:::
  Fly  1298 KNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIE 1362

Human  1420 TFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKL 1484
            ...|.|.|||:|||.:.||.|||||:||.||||||||::|.||||....:|..:|:|||::.||.
  Fly  1363 AAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKS 1427

Human  1485 VVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTA 1549
            .||:|..||:..|.|||||.|.|||||.|||||.:|||.:.::|||||::|:.|::::||.:.|.
  Fly  1428 FVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTE 1492

Human  1550 FADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1601
            |.:.||:|||||::|||.:|.||||.:|.|:||..|.:||....|.|.|..:
  Fly  1493 FKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC8	XP_016873686.1	None
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	493/1547 (32%)
		ABC_membrane	338..601	CDD:279056	91/286 (32%)
		ABCC_MRP_domain1	649..848	CDD:213217	98/268 (37%)
		ABC_membrane	988..1260	CDD:279056	88/288 (31%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	119/219 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650