Protein Alignment SUPT6H and CG31156

DIOPT Version :10

• Sequence 1: NP_003161.2
• Gene: SUPT6H / 6830
• HGNCID: 11470
• Length: 1726
• Species: Homo sapiens
• Sequence 2: NP_651070.3
• Gene: CG31156 / 42669
• FlyBaseID: FBgn0051156
• Length: 948
• Species: Drosophila melanogaster
• Alignment Length: 1366
• Identity: 255/1366 - (18%)
• Similarity: 449/1366 - (32%)
• Gaps: 515/1366 - (37%)

Human    27 TKKFVEEEDDDEEEEEENLDDQDEQGNLKGFINDDDDEDEGEEDEGSD-SGDSEDDVGHKKR--- 87
            |||.|.|           :.|.||:.||..   |||...|..:....| :.|::..|..::|
  Fly    11 TKKIVIE-----------ISDSDEEVNLTA---DDDYRPEETKSRIIDRAADAQTVVTKRQRFPT 61

Human    88 -KRTSFDDRLEDDDFDLIEENLGVKVKRGQKYRRVKKMSDDEDDDEEEYGKEEHEKEAIAEEIFQ 151
             |:|:             .|....|.|||           |::..:|.....|:..|::.::...
  Fly    62 SKKTA-------------AEGPAPKKKRG-----------DKEKADENACPNENNPESVVQDTPS 102

Human   152 DGEGEEG----QEAMEAPMAPPEEEEEDDEESDIDDFIVDDDGQPLKKPKWRKKLPGYTDAALQE 212
            ......|    :...||| ||..:....|:|.                              |:.
  Fly   103 TSNQRNGAVGTEHNSEAP-APKRKRARKDKED------------------------------LKT 136

Human   213 AQEIFGVDFDYDEFEKYNEYDEELEEEYEYEDDEAEGEIRVRPKKTTKKRVSRRSIFEMYEPSEL 277
            |.               ||.:.|            :|::......|              :|:::
  Fly   137 AA---------------NETNPE------------KGDVVPSTAVT--------------QPNDI 160

Human   278 ESSHLTDQDNEIRATDLPERFQLRSIPVKGAEDDELEEEADWIYRNAFATPTISLQESCDYLDRG 342
            .:|...::.:..|:: ..||.::.:|       |||..|.:.|
  Fly   161 VASSSHNKSSTGRSS-FWERRKVWNI-------DELLAETESI---------------------- 195

Human   343 QPASSFSRKGPSTIQKIKEALGFMRNQHFEVPFIAFYRKEYVE---PELHINDLWRVWQWDEKWT 404
            ||.::      ..|.|:.|       ....:|||..||::.|:   |: .:.|:...:   .:..
  Fly   196 QPQAA------RNIVKLFE-------DENTIPFICRYRRDLVDHIAPD-RLRDIRNTY---TEIV 243

Human   405 QLRIRKENLTRLFEKMQAYQYEQISADPDKPLADGIRALDTTDMERLKDVQSMDELKDVYNHFLL 469
            .||.|.||:      :...|.|.|       :...||       |.|...:|.:||:.:|..:
  Fly   244 DLRKRAENI------IGKLQRENI-------MTPEIR-------EELMCAKSNEELEFLYAPY-- 286

Human   470 YYGRDIPKMQNAAKASRKKLKRVREEGDEEGEGDEAEDEEQRGPELKQASRRDMYTICQSAGLDG 534
                                                          |.||:..:....::.||..
  Fly   287 ----------------------------------------------KPASKGTLAERAKALGLQV 305

Human   535 LAK--KFGLTPEQFGENLRDSYQRHETEQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIA 597
            .|.  .:|..|:   .||.:...| ..|....|.|                |:.|...::...|:
  Fly   306 YADCLLYGSAPK---VNLSEIVDR-RNEALATEAL----------------VMSGICQIIIHNIS 350

Human   598 REPLVRQVLRQTFQ-ERAKLNITPTKKGR---------------------KDVDEAHYAYSFKYL 640
            :...|.:.:|:... .|..|..:.||:.:                     |.:|.:.:...|.:
  Fly   351 KNTNVLEEIRRLQNVHRVFLKCSKTKEAKSSKSSSSSKASSSKGSNQNADKKLDSSKFENYFNF- 414

Human   641 KNKPVKELRDDQFLKICLAEDEGLLTTDISIDLKGVEGYGNDQTYFEEIKQFYYRDEFSHQVQEW 705
             ...||.::..|.|.|...|....|:..|..         ||  |.:.....|..|::.:|..::
  Fly   415 -QGDVKTIKPYQMLAINRGEKHKWLSVKIET---------ND--YLKRDLMRYITDQYMNQGLQY 467

Human   706 NRQR---TMAIERALQQFLYVQMAKELKNKLLAEAKEYVIKACSRKLYNWLRVAPYRPDQQVEED 767
            ..:|   |.::|....:.|...|.::::..|..:..:..|...::.|...|.::|.
  Fly   468 PLRREVFTKSLEECYAKKLQPLMCRQIRAALKEKGTKAAIDVFAKNLKQLLLISPL--------- 523

Human   768 DDFMDENQGKGIRVLGIAFSSARDHPVFCALVNG-----EGEVTDFLR----LPHFTKRRTAWRE 823
                     ||.|:|||       .|.|   :||     ..|..|.|.    .||..
  Fly   524 ---------KGERILGI-------DPGF---INGCKLALISETADVLYTGVIYPHGA-------- 561

Human   824 EEREKKAQDIETLKKFLLNKKPHVVTVAGENRDAQMLIEDVKRIV------------HELD---Q 873
                            :.||:      |.|.:..|:|.:...:|:            |.|.   .
  Fly   562 ----------------MSNKR------AAEQKLVQLLSDHNCKIIGLGNGTACRETEHWLTGMFH 604

Human   874 GQQLSS--IGVELVDNELAILYMNSKKSEAEFRDYPPVLRQAVSLARRIQDPLIEFAQVCSSDED 936
            ...|.|  |...:|:...|.:|..|..:..||.......|.|||:|||:.|||.|:
  Fly   605 AGVLDSRIIRYSIVNENGASIYSCSNVAAKEFPKMDTNERSAVSIARRLNDPLSEY--------- 660

Human   937 ILCLKFHP------LQEHVVKEELLNALYCEFINR-VNEVGVDVNRAIAHPYSQALIQYVCGLGP 994
               :|..|      :.:|.|.|::|.|...:.::. |:.||||:|.|     |.::::::.||..
  Fly   661 ---VKIEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLNTA-----SLSVLKHIAGLSE 717

Human   995 RKGTHLLKILKQNNTRLESRTQLVTMCHMGPKVFMNCAGFLKIDTASLGDSTDSYIEVLDGSRVH 1059
            :|...:::...|... .::|..|:::..:|.|.|:.||||::|:..|:|....:   .||.:.||
  Fly   718 KKAEKIIEHRTQKGP-FKTRKDLLSVRSIGEKSFVQCAGFVRIEPRSVGGQLQN---PLDCTWVH 778

Human  1060 PETYEWARKMAVDAL--EYDESAEDANPAGALEEILENPERLKDLD------------LDAFAEE 1110
            ||:|.     .|:::  |.|....|...|..:..|.:......:||            |:.....
  Fly   779 PESYN-----VVESIVGECDLKLSDVGKAAFIASIKQFASSQPNLDRIAKQHKLPMERLEFLLVA 838

Human  1111 LERQGYGDKHITLYDIRAELSCRYKDLRTAYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIA 1175
            |:|:       .|.|.||:|     |.|..::...|.          .:...:|:::...||.:.
  Fly   839 LQRE-------LLQDYRADL-----DKRPLFKQGLTR----------LDDLSMGEVVTGAVTNVT 881

Human  1176 HRRPQGESYDQAIRNDETGLWQCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVKTRLDNGVTGFI 1240
                                      |...|.:                 :||:.      .|.|
  Fly   882 --------------------------QFGAFVD-----------------VGVER------NGLI 897

Human  1241 PTKFLSDKVVKRPEERVKVGMTVHCRIMKIDIEKFSADLTCRTSDLMDRNNEWKLPKDTYYDFDA 1305
            ....:::       .::.||..:...::|:|:::...:|  |..:::       :..||.:.|.|
  Fly   898 HNSNMNN-------SQLSVGDRIVASVVKVDLKRRQLEL--RLENML-------METDTSFKFKA 946

Human  1306 E 1306
            |
  Fly   947 E 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUPT6H	NP_003161.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..199		37/180 (21%)
		Interaction with PAAF1. /evidence=ECO:0000269|PubMed:22316138	2..916		170/953 (18%)
		Interaction with IWS1. /evidence=ECO:0000250	2..485		84/469 (18%)
		Interaction with KDM6A. /evidence=ECO:0000250	317..1300		197/1059 (19%)
		HTH_44	<347..422	CDD:464230	16/77 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..520		2/35 (6%)
		Tex	564..1130	CDD:441786	135/637 (21%)
		YqgF	775..931	CDD:258777	44/181 (24%)
		HHH_7	935..1038	CDD:291309	28/109 (26%)
		S1	<1227..1282	CDD:197648	9/54 (17%)
		SH2_2	1308..1512	CDD:464227
		Interaction with histone H2B and H3. /evidence=ECO:0000269|PubMed:10933715	1633..1726
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1726
CG31156	NP_651070.3	Tex	184..932	CDD:441786	201/1058 (19%)