DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cacna1s and para

DIOPT Version :9

Sequence 1:NP_446325.1 Gene:Cacna1s / 682930 RGDID:70983 Length:1850 Species:Rattus norvegicus
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2165 Identity:505/2165 - (23%)
Similarity:851/2165 - (39%) Gaps:674/2165 - (31%)


- Green bases have known domain annotations that are detailed below.


  Rat    29 RALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93
            :|::.|...||:|:..|.::....|...|:.||..||:.:.    ||....      :|..|..|
  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VESTEVIF 185

  Rat    94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAG 158
            ..:::.|:|:|::|.||:.....|||..||.|||:::.|...|..::..|:              
  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNL-------------- 236

  Rat   159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223
               .|||.|||||.|:.|:.||.|:.::.::.:::..|..:.:|.:|.:.::|::||:::.|.:.
  Fly   237 ---AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLT 298

  Rat   224 KTCY----FIG-----TDIVATVENEKPSP------------CARTGSGRPCTINGSECRGGWPG 267
            :.|.    ..|     ||......|...|.            |........|..:....:|..|.
  Fly   299 QKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPN 363

  Rat   268 PNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGV 332
            ||:|.|.||:||::.|:.::.::.:.|.|:...|..|.| .|..::|:.:|.||||:::||:|.:
  Fly   364 PNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAI 427

  Rat   333 LSGEFTKEREKAKSRGTFQK--LREKQQ--------LEE-------------------------- 361
            ::..:.:.::||:.....::  :||.::        |||                          
  Fly   428 VAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAK 492

  Rat   362 ----------------------------------------------------------------- 361
                                                                             
  Fly   493 SPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSL 557

  Rat   362 ----------------------------------------------------------------- 361
                                                                             
  Fly   558 SLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEE 622

  Rat   362 ---------------------------------DLRGYMSWI----------------------- 370
                                             ||.|.|:.:                       
  Fly   623 NGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGA 687

  Rat   371 TQGEVMDVD-----DLREGKLSL---DEGGS------------DTESLYEIEG---LNKIIQFI- 411
            |.|....:|     |.|:.::.|   ||.|.            .|:::.:::.   ||.||:.. 
  Fly   688 TNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAA 752

  Rat   412 -RHWRQWNR-----------------VFRWKCHDLVKSKV---------FYWL------------ 437
             ||.|..:|                 .|:.|..:::...:         :.||            
  Fly   753 GRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFD 817

  Rat   438 ------VILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEMLMKMYGLGLRQYFMSIF 496
                  :.|.:.:||:.:|.:||:....:..:....|....|.|.||..||:..:..:.||...:
  Fly   818 PFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGW 882

  Rat   497 NRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIAS 561
            |.||..:|...:||:     |.....|:||||..||||:||:.|.|.:|:.|::.:..::.::.:
  Fly   883 NIFDFIIVALSLLEL-----GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGN 942

  Rat   562 LLLLLFLFMIIFALLGMQLFGGRYD-----FEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMY 621
            |..:|.:.:.|||::||||||..|.     |.|.::.|.||.:|..:.:.||:||.|| |...|:
  Fly   943 LTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMW 1006

  Rat   622 NGIMAYGGPSYPGVLVCI-YFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERK--- 682
            :.:       |.|.:.|| :|:...|.||.::||:|||:.:.|.  ..|..||..|..:..|   
  Fly  1007 DCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNF--GSSSLSAPTADNDTNKIAE 1062

  Rat   683 --------RRKMSRGLPDKSEEERSTMTKKLEQKPKGE--------------------------- 712
                    :..:.|.:.|..:..|:.:|.::..:|.||                           
  Fly  1063 AFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISAEHGDNE 1127

  Rat   713 ----------------GIPTTAKLKI-----------------------------DEFESNVNEV 732
                            ||....:|::                             |:..:::|..
  Fly  1128 LELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSY 1192

  Rat   733 ----KDPYPSADFPGDDE--EDEPEIPASPRPRPLAELQLKE----------------------- 768
                ..|:......|..|  |.|.:..||.....|.| :|.|                       
  Fly  1193 GSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDE-ELDEEGECEEGPLDGDIIIHAHDEDIL 1256

  Rat   769 -------------KAVPI---PEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALA 817
                         |..||   .:.|.|  :.....:|:...:::...:|...::..||:||.|||
  Fly  1257 DEYPADCCPDSYYKKFPILAGDDDSPF--WQGWGNLRLKTFQLIENKYFETAVITMILMSSLALA 1319

  Rat   818 AED------PIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVV 876
            .||      ||..|     ||.|.|.:||.:|.:|:::|....|..:    :..|.:..||.::|
  Fly  1320 LEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIV 1375

  Rat   877 AVSLISMG---LESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLL 938
            .||||:..   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::||..:.
  Fly  1376 MVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIF 1440

  Rat   939 QFMFACIGVQLFKGKFYSCNDL--SKMTEE------ECRGYYYIYKDGDPTQIELRPRQWIHNDF 995
            ..:||.:|||||.||::.|.|:  :|::.|      .|....|               .|:::..
  Fly  1441 WLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENY---------------TWVNSAM 1490

  Rat   996 HFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIF 1060
            :||:|.:|.:.||.|:||:||.|::..||||.|.|..|:....:.|.::|:.:||..:||.:|:|
  Fly  1491 NFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLF 1555

  Rat  1061 VGFVIVTFQEQGETEYKNCELDKNQRQCVQY-ALK----ARPLRCYIPKNPYQYQ--VWYVVTSS 1118
            :|.:|..|.||.:....:.|:...:.|...| |:|    .:||:. ||:..::.|  |:.:||..
  Fly  1556 IGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKA-IPRPRWRPQAIVFEIVTDK 1619

  Rat  1119 YFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWN 1183
            .|:.::...|.||...:.:..|:.|:..|.:.|.||..|.:||:.|.:||:.|.:.. ||.:|||
  Fly  1620 KFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH-YFIEPWN 1683

  Rat  1184 VFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVM---RLIK 1245
            :||.::||.||:.::||:|                      .|...:|....|:.||.   |:::
  Fly  1684 LFDVVVVILSILGLVLSDI----------------------IEKYFVSPTLLRVVRVAKVGRVLR 1726

  Rat  1246 LLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFP 1310
            |:..|:|:||||:....|..||..:.||:.::.||:|:.||..|..:....|  ||...||:||.
  Fly  1727 LVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFG 1789

  Rat  1311 QAVLLLFRCATGEAWQEILLACSYGKRCDP---ESDYAPGEEYACGTNFAYYYFISFYMLCAFLI 1372
            |:::|||:.:|...|..:|.|....:.|||   :..| ||.   ||:......|:..|::.:|||
  Fly  1790 QSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGY-PGN---CGSATVGITFLLSYLVISFLI 1850

  Rat  1373 -INLFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGF 1435
             ||:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||..
  Fly  1851 VINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQI 1915

  Rat  1436 GKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGN-FEQANE--ELRA----- 1492
            .|  |::.   :::.|::|:.....:.....|.||.:.....|  || .|:..|  |:.|     
  Fly  1916 HK--PNKY---KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGEIGEIAARPDTE 1973

  Rat  1493 ----IIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDTV 1553
                :...:|::.                    :.|...|||..:||...|.|....:.|  ||.
  Fly  1974 GYEPVSSTLWRQR--------------------EEYCARLIQHAWRKHKARGEGGGSFEP--DTD 2016

  Rat  1554 QIQAGLRTIEEEAA-PEIHRAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNS 1617
            ....|    :.:|. |....|..||..|                     ||     |..:..|  
  Fly  2017 HGDGG----DPDAGDPAPDEATDGDAPA---------------------GG-----DGSVNGT-- 2049

  Rat  1618 LPPVMANQRPLQFAEMEMEELESPVFLEDFPQNPGTHPLARANTNNANANVAYGNSSHRNSPVFS 1682
                         ||...:..||.|      .:||....|.|   .|.|..|...::...||...
  Fly  2050 -------------AEGAADADESNV------NSPGEDAAAAA---AAAAAAAAAGTTTAGSPGAG 2092

  Rat  1683 SIRYERELLEEAGRPVTREG 1702
            |...:..:|.|:...||:.|
  Fly  2093 SAGRQTAVLVESDGFVTKNG 2112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cacna1sNP_446325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 86/319 (27%)
Ion_trans 50..345 CDD:306908 83/315 (26%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 8/236 (3%)
II. /evidence=ECO:0000305 418..664 81/295 (27%)
Ion_trans 431..672 CDD:306908 80/273 (29%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..717 12/97 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..758 7/32 (22%)
III. /evidence=ECO:0000305 786..1068 98/298 (33%)
Ion_trans 798..1075 CDD:306908 100/293 (34%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 33/88 (38%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 92/287 (32%)
Ion_trans 1117..1392 CDD:306908 91/282 (32%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 23/70 (33%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 15/43 (35%)
GPHH 1393..1463 CDD:318993 16/69 (23%)
Ca_chan_IQ 1465..1536 CDD:312334 16/82 (20%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 7/19 (37%)
CAC1F_C 1558..1838 CDD:318975 31/146 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1697..1779 3/6 (50%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 78/298 (26%)
Na_trans_cytopl 515..648 CDD:288761 0/132 (0%)
Ion_trans 835..1028 CDD:278921 66/205 (32%)
Na_trans_assoc 1054..1296 CDD:284034 30/244 (12%)
Ion_trans 1318..1571 CDD:278921 94/276 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/52 (25%)
Ion_trans 1636..1871 CDD:278921 87/263 (33%)
GPHH 1880..1930 CDD:293510 14/54 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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