DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STYX and Mkp3

DIOPT Version :9

Sequence 1:	NP_001124173.1	Gene:	STYX / 6815	HGNCID:	11447	Length:	223	Species:	Homo sapiens
Sequence 2:	NP_001262031.1	Gene:	Mkp3 / 40081	FlyBaseID:	FBgn0036844	Length:	497	Species:	Drosophila melanogaster

Alignment Length:	146	Identity:	49/146 - (33%)
Similarity:	84/146 - (57%)	Gaps:	12/146 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    31 EILPG-LFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPN-FQQL--FRYLVLDIADNP 91
            ||:|| ||||..:.:..|:  .|:|:.|.:::.:..::      || |::.  .:||.:.|.|:.
  Fly   217 EIIPGLLFLGNATHSCDSE--ALKKYNIKYVLNVTPDL------PNKFKESGDIKYLQIPITDHY 273

Human    92 VENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFC 156
            .:::...||...:||:.:......||||..||:|||....:||:|.|.|:...||||.|::|:..
  Fly   274 SQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPD 338

Human   157 INPNAGFVHQLQEYEA 172
            ::||..|:.||..:|:
  Fly   339 VSPNFHFMQQLLSFES 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STYX	NP_001124173.1	DSP_STYX	25..175	CDD:350372	49/146 (34%)
		Interaction with FBXW7. /evidence=ECO:0000269\|PubMed:28007894	76..78		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..223
Mkp3	NP_001262031.1	DSP_MapKP	8..148	CDD:238723
		DSPc	215..353	CDD:238073	48/143 (34%)
		CDC14	<242..359	CDD:225297	38/119 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910