Protein Alignment STXBP1 and SEC1

DIOPT Version :10

• Sequence 1: NP_003156.1
• Gene: STXBP1 / 6812
• HGNCID: 11444
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_010448.1
• Gene: SEC1 / 851742
• SGDID: S000002571
• Length: 724
• Species: Saccharomyces cerevisiae
• Alignment Length: 649
• Identity: 164/649 - (25%)
• Similarity: 309/649 - (47%)
• Gaps: 84/649 - (12%)

Human    18 VIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINK-RREPLPSLEAVYLITPSE 81
            |:.:::.|...|.|::|:....:||........:...:|.|:.|:. .|:...|:||:|::.|::
Yeast    15 VLNQIETKNNLKFLIIDKTVETILSYLFLTPQELLNNVTSVDLIDSPTRKGQSSIEAIYILEPTK 79

Human    82 KSVHSLISDFK-DPPTAKYRAAHVFFTDSCPDALFNELVKSR-AAKVIKTLTEINIAFLPYESQV 144
            .:::.:.:||. .||  |||..|:.|.....:.:|......| .|:.:::...|.:.|...|||.
Yeast    80 YNINCIDADFMVRPP--KYRRCHIRFLPGLTNPIFQFFQSKRYIAQNLESFKPIELGFFVKESQF 142

Human   145 Y-SLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYR----GEYKD------- 197
            : :|....|.|.|::.:...:....:.::...:.:||....|||.|||.    .|.:|
Yeast   143 FETLQMEHSLQVFFNNNCKALIPTNVRKIVGSLVSLCVITGEYPIVRYSVSNPVEEEDARNGNAV 207

Human   198 ---NAL---LAQLIQDKLDAYKADDPTM-GEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYD 255
               |:|   :|...|..:|.|..::|.. .:..::.||.|:|.||..||.:|:||:.::|||:||
Yeast   208 VNANSLTRSIANAFQIAIDTYARNNPDFPPQNTERPRSILIITDRTLDPFAPILHDFSYQAMAYD 272

Human   256 L---LPIENDVYKYET---SGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSK 314
            |   :..:.|:|.|..   :|..|.:|.: |:|..|..||.|:|:||.:.::.:...:|:..:..
Yeast   273 LVANVDTQKDIYHYSAENEAGEQEEKVSK-LVDLYDPDWIDLKHQHIMDANEYIQGRIKELIAKN 336

Human   315 -----RMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCM-KHYQGTVDKLCRVEQDLA 373
                 |.|....|   ||..::..:..:.:|..:...|..|.::|: ::.:..:..:..:||:|:
Yeast   337 PLLVDRSNVKNTT---DLLSVVAHLKDFDEERRRLILHKTLVDECLGENAERKLADISAIEQNLS 398

Human   374 -MGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDS 437
             .|.|..|||||..:..::|.|.....:..||:|.|:.|...:.||.|.:..||:....:..|..
Yeast   399 GFGMDFSGEKIKHIIDDLLPALAMKEPTILDKLRYIIAYALFRGGIIELDFIKLLNFIGVTHEHE 463

Human   438 ------EIITNMAHLGVPIVTDSTLRRRSKPERKERISE------QTYQLSRWTPIIKDIMEDTI 490
                  :|..|...:...::.|   :.:.||.:||...:      ..|..||:.|.:.:|:...|
Yeast   464 NFQQYLKIFRNYDLIDFKLIKD---KPKDKPFQKEWFHDTLVNDPNIYHTSRFVPAVGNILSKVI 525

Human   491 EDK--LDTKHYPYISTR----------------SSASFSTTAVSARYGHWHKNKAPGEYRSGP-- 535
            .:.  |..:::||:..:                :||:.|::..:.|:......|:....::.|
Yeast   526 ANPLLLSEQYFPYLKDKPIELLNEEEFQAGLANTSANSSSSLRNPRHKAAWTTKSSNIKKNIPRQ 590

Human   536 RLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPTKFLMD---LRHP----DFRESSR 592
            |...:::||:|:.|::.||:.:....: ::.|||..||||||||.:   |::|    .|:|..|
Yeast   591 RFFYYVIGGISIPEIKAAYDQSNLKNR-DIFIGSDEILTPTKFLDEVERLQNPREFFKFKEDQR 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STXBP1	NP_003156.1	Sec1	29..579	CDD:460020	155/616 (25%)
SEC1	NP_010448.1	SEC1	1..644	CDD:227487	161/638 (25%)