Protein Alignment STXBP1 and stxbp1a

DIOPT Version :10

• Sequence 1: NP_003156.1
• Gene: STXBP1 / 6812
• HGNCID: 11444
• Length: 603
• Species: Homo sapiens
• Sequence 2: XP_005161170.1
• Gene: stxbp1a / 574003
• ZFINID: ZDB-GENE-050626-106
• Length: 603
• Species: Danio rerio
• Alignment Length: 603
• Identity: 531/603 - (88%)
• Similarity: 576/603 - (95%)
• Gaps: 0/603 - (0%)

Human     1 MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRR 65
            |||||||||||||||:|||||||||||||.|:|||||||||||||||||||||||||||||.|||
Zfish     1 MAPIGLKAVVGEKIMNDVIKKVKKKGEWKALIVDQLSMRMLSSCCKMTDIMTEGITIVEDIMKRR 65

Human    66 EPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTL 130
            ||||||||:|||||::|||.:||:|||||.:|||:.|||||||||||.||||:|||||:|.||||
Zfish    66 EPLPSLEAIYLITPTDKSVQTLINDFKDPHSAKYKGAHVFFTDSCPDPLFNEVVKSRASKTIKTL 130

Human   131 TEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEY 195
            .|||||||||||||:|||:.|:|||||||||.|:|||::||||||:|||||||||||||||||||
Zfish   131 NEINIAFLPYESQVFSLDNPDAFQSFYSPHKTQLKNPVMERLAEQLATLCATLKEYPAVRYRGEY 195

Human   196 KDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIE 260
            ||||.||||:|||||||||||||||||||||||||:||||||||.||||||||||||:|||||||
Zfish   196 KDNATLAQLLQDKLDAYKADDPTMGEGPDKARSQLIILDRGFDPVSPVLHELTFQAMAYDLLPIE 260

Human   261 NDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMR 325
            ||||||:|||||::|.|||||.||||||:|||||||||||||||||||:||:|||||||||||||
Zfish   261 NDVYKYDTSGIGDSREKEVLLHEDDDLWVALRHKHIAEVSQEVTRSLKEFSASKRMNTGEKTTMR 325

Human   326 DLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAI 390
            |||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
Zfish   326 DLSQMLKKMPQYQKELSKYSTHLQLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAI 390

Human   391 VPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDST 455
            |||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Zfish   391 VPILLDANVTTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIITDST 455

Human   456 LRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYG 520
            |||..|.:||||:||||||||||||:|||||||.|:||||||||||||||||:||||:|||||||
Zfish   456 LRRGKKMDRKERVSEQTYQLSRWTPLIKDIMEDAIDDKLDTKHYPYISTRSSSSFSTSAVSARYG 520

Human   521 HWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPTKFLMDLRHP 585
            ||||||.|||||:|||:::||:||.|.:||||||||||||||||.::||||.|||||||||||||
Zfish   521 HWHKNKTPGEYRTGPRIMVFIIGGASFSEMRCAYEVTQANGKWEAIVGSTHSLTPTKFLMDLRHP 585

Human   586 DFRESSRVSFEDQAPTME 603
            |||||:||||||..|:.|
Zfish   586 DFRESTRVSFEDPDPSDE 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STXBP1	NP_003156.1	Sec1	29..579	CDD:460020	483/549 (88%)
stxbp1a	XP_005161170.1	Sec1	29..579	CDD:460020	483/549 (88%)