Protein Alignment STXBP1 and unc-18

DIOPT Version :10

• Sequence 1: NP_003156.1
• Gene: STXBP1 / 6812
• HGNCID: 11444
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_001024606.1
• Gene: unc-18 / 181030
• WormBaseID: WBGene00006757
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 591
• Identity: 349/591 - (59%)
• Similarity: 445/591 - (75%)
• Gaps: 19/591 - (3%)

Human     4 IGLKAVVGEKIMHDVIKKVKK---KGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRR 65
            :.||.:||.|:::|||:.:||   :..|.||:||.|:||||||||||.:||.||||||||:||||
 Worm     1 MSLKQIVGHKLLNDVIRPLKKGDGRSAWNVLIVDTLAMRMLSSCCKMHNIMEEGITIVEDLNKRR 65

Human    66 EPLPSLEAVYLITPSEKSVHSLISDFKDPPTAK--YRAAHVFFTDSCPDALFNELVKSRAAKVIK 128
            ||||:|||:|||.|:.:|:..||.|:    .|:  |:.||||||::|.|.||:.|.||.||:.||
 Worm    66 EPLPTLEAIYLIAPTAESIDKLIQDY----CARNLYKCAHVFFTEACSDQLFSTLSKSAAARFIK 126

Human   129 TLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRG 193
            ||.||||||.||||||::|||.|:|..:|:..|.......|||:||||||:||||.|||::|||.
 Worm   127 TLKEINIAFTPYESQVFNLDSPDTFFLYYNAQKQGGLTSNLERIAEQIATVCATLGEYPSLRYRA 191

Human   194 EYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLP 258
            :::.|..|..|::.||||||||||:||||.|||||||:|:|||:|..:|:|||||.|||.||||.
 Worm   192 DFERNVELGHLVEQKLDAYKADDPSMGEGADKARSQLIIIDRGYDAITPLLHELTLQAMCYDLLG 256

Human   259 IENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTT 323
            ||||||||||.|..|...|||||||:||||:.:||||||.||||||::||.||.||    |.|.|
 Worm   257 IENDVYKYETGGSDENLEKEVLLDENDDLWVEMRHKHIAVVSQEVTKNLKKFSESK----GNKGT 317

Human   324 M-----RDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKI 383
            |     :|||.::|:|||::|||:|:|||:.|||:|||.||..|||||:|||||:.|.|||||::
 Worm   318 MDSKSIKDLSMLIKRMPQHKKELNKFSTHISLAEECMKQYQQGVDKLCKVEQDLSTGIDAEGERV 382

Human   384 KDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGV 448
            :|.|:.:||:|:|..|...|::|:|||||..|||||:||||||:|||.|...|.|.|||.|:||:
 Worm   383 RDAMKLMVPLLIDPAVRCEDRLRLILLYILSKNGITDENLNKLLQHANISMADKETITNAAYLGL 447

Human   449 PIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTT 513
            .||||:..::...|.:|||..||.||.|||.|:||||:||.|:::|||||:|:::.|........
 Worm   448 NIVTDTGRKKTWTPTKKERPHEQVYQSSRWVPVIKDIIEDAIDERLDTKHFPFLAGRQVNQGYRA 512

Human   514 AVSARYGHWHKNKA-PGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPTK 577
            ..|||||.|||.:. ...|||||||||:|:|||:.:|||..||||.|...|||:|||..|:||.|
 Worm   513 PASARYGQWHKERGQQSNYRSGPRLIIYIIGGVTFSEMRACYEVTAARKPWEVVIGSDRIITPDK 577

Human   578 FLMDLR 583
            ||.:||
 Worm   578 FLTNLR 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STXBP1	NP_003156.1	Sec1	29..579	CDD:460020	334/557 (60%)
unc-18	NP_001024606.1	Sec1	30..579	CDD:460020	334/556 (60%)