Protein Alignment STX3 and Syx1A

DIOPT Version :10

• Sequence 1: XP_016873680.2
• Gene: STX3 / 6809
• HGNCID: 11438
• Length: 299
• Species: Homo sapiens
• Sequence 2: NP_001189276.1
• Gene: Syx1A / 42854
• FlyBaseID: FBgn0013343
• Length: 296
• Species: Drosophila melanogaster
• Alignment Length: 284
• Identity: 163/284 - (57%)
• Similarity: 221/284 - (77%)
• Gaps: 12/284 - (4%)

Human    12 KLPLIHPMMKQLTQDDDTDAVEIAID---NTAFMDEFFSEIEETRLNIDKISEHVEEAKKLYSII 73
            :|..:|     ..|.||.:..|:|::   :.::||:||:::||.|..|||:.::|||.||.:|.|
  Fly     5 RLAALH-----AAQSDDEEETEVAVNVDGHDSYMDDFFAQVEEIRGMIDKVQDNVEEVKKKHSAI 64

Human    74 LSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHIEEDEV--RSSADLRIRKSQHSVLSRK 136
            ||||..:.|||.:||.|..:|||.||.||.|||.:|::||::|.  :|||||||||:|||.||||
  Fly    65 LSAPQTDEKTKQELEDLMADIKKNANRVRGKLKGIEQNIEQEEQQNKSSADLRIRKTQHSTLSRK 129

Human   137 FVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKTTDEELEEMLESGNPAIFTSGII-DSQISKQA 200
            ||||||:||..|.|:|||.||||||||||||:.|.|:|||:|||.||.::||.||| ::|.:||.
  Fly   130 FVEVMTEYNRTQTDYRERCKGRIQRQLEITGRPTNDDELEKMLEEGNSSVFTQGIIMETQQAKQT 194

Human   201 LSEIEGRHKDIVRLESSIKELHDMFMDIAMLVENQGEMLDNIELNVMHTVDHVEKARDETKKAVK 265
            |::||.||:||::||:|||||||||||:|||||:||||:|.||.:|.|.:|:|:.|..:||||:|
  Fly   195 LADIEARHQDIMKLETSIKELHDMFMDMAMLVESQGEMIDRIEYHVEHAMDYVQTATQDTKKALK 259

Human   266 YQSQARKKLIIIIVLVVVLLGILA 289
            |||:||:|.|:|::.:.| |||||
  Fly   260 YQSKARRKKIMILICLTV-LGILA 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STX3	XP_016873680.2	Syntaxin	44..236	CDD:459942	123/194 (63%)
		SNARE	204..270	CDD:473982	44/65 (68%)
Syx1A	NP_001189276.1	Syntaxin	35..230	CDD:459942	123/194 (63%)
		SNARE	231..281	CDD:461727	26/50 (52%)