DRSC/TRiP Functional Genomics Resources

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Protein Alignment STK11 and TOS3

DIOPT Version :10

Sequence 1:NP_000446.1 Gene:STK11 / 6794 HGNCID:11389 Length:433 Species:Homo sapiens
Sequence 2:NP_011336.3 Gene:TOS3 / 852696 SGDID:S000003147 Length:560 Species:Saccharomyces cerevisiae


Alignment Length:412 Identity:119/412 - (28%)
Similarity:187/412 - (45%) Gaps:86/412 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    28 RIDST---EVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLR--- 86
            ||..|   :::|.|..|| :::..:.:...||.|.|||||...|..|....|:|||.:.:.|   
Yeast    27 RIKETRKVKLLYNPLTKR-QILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGY 90

Human    87 ----RIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKR 147
                ::.|...|  :||::::|..|:||::|.::|.:.|..|:|:|:|||..|..:.   .||.:
Yeast    91 SLQLKVENPRVN--QEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKW---CPENK 150

Human   148 FPV----------CQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALH 202
            ..:          .|:......::.||||||||||.|:||||.|||:::.||:||||.|||.:..
Yeast   151 MEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTA 215

Human   203 PFAADDTCRTSQ-------GSPAFQPPEIANGLDTFS-GFKVDIWSAGVTLYNITTGLYPFEGDN 259
            ..:.:......|       |:|||..||:.:....:| ...:||||.|||:|.:..|..||..::
Yeast   216 TGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANS 280

Human   260 IYKLFENIGKGSYAIP--------GDCGPPL------SDLLKGMLEYEPAKRFSIRQIRQHSWFR 310
            ..:||::|.......|        ...|..:      .||||.:|:.:|.||..:..|:.|. |.
Yeast   281 GLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHP-FM 344

Human   311 KKHPPAEAPVPI------------PPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYT 363
            ..:..::|...:            |||...:....|:.|......|              |.:|.
Yeast   345 CHYGKSDAASVLTNLETFHELKVSPPSSCKRVELVSLPVNSSFASL--------------DSVYM 395

Human   364 QDFTVPGQVPEEEASHNGQRRG 385
            ::|           .||..|.|
Yeast   396 ENF-----------DHNNLRTG 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STK11NP_000446.1 Sufficient for interaction with SIRT1. /evidence=ECO:0000269|PubMed:18687677 45..90 15/51 (29%)
STKc_LKB1 55..309 CDD:271021 97/292 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..331 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433
TOS3NP_011336.3 STKc_LKB1_CaMKK 56..344 CDD:270910 97/293 (33%)
Blue background indicates that the domain is not in the aligned region.

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