DRSC/TRiP Functional Genomics Resources

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Protein Alignment STK11 and stk11

DIOPT Version :10

Sequence 1:NP_000446.1 Gene:STK11 / 6794 HGNCID:11389 Length:433 Species:Homo sapiens
Sequence 2:NP_001016533.1 Gene:stk11 / 549287 XenbaseID:XB-GENE-955279 Length:432 Species:Xenopus tropicalis


Alignment Length:427 Identity:354/427 - (82%)
Similarity:381/427 - (89%) Gaps:7/427 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     7 QQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSET 71
            |::|..  |:| |||||||||||||||||||||||||||:|||||||||||||||||||:|||:|
 Frog    13 QEIGFL--GDL-SVGMDTFIHRIDSTEVIYQPRRKRAKLVGKYLMGDLLGEGSYGKVKEMLDSDT 74

Human    72 LCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGM 136
            ||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||
 Frog    75 LCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGM 139

Human   137 QEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEAL 201
            |||||||.||.|||.|||||||||||||||||||||||||||||||||||.||||||||||||||
 Frog   140 QEMLDSVQEKHFPVFQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTDGTLKISDLGVAEAL 204

Human   202 HPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFEN 266
            ||||..|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   205 HPFAEGDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFEN 269

Human   267 IGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDR 331
            ||||.|:||.:|||.|||||:|||||:|||||||:|||||:|||||||..:..|||||||:||||
 Frog   270 IGKGDYSIPEECGPLLSDLLRGMLEYDPAKRFSIQQIRQHNWFRKKHPHMDPIVPIPPSPETKDR 334

Human   332 WRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTE 396
            |||:|||||||||||..|:|||.|:||||||||||||||||.|::.....|.....|.:||||||
 Frog   335 WRSLTVVPYLEDLHGYSEEEDLCDLEDDIIYTQDFTVPGQVAEDDYFAQTQSTAPSKQLCMNGTE 399

Human   397 AAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ 433
             .||.|:.|.   :.:..|||.:|.||:|:|||||||
 Frog   400 -NQLKTERRV---SSSSQRKASTAGSKVRKLSACKQQ 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STK11NP_000446.1 Sufficient for interaction with SIRT1. /evidence=ECO:0000269|PubMed:18687677 45..90 41/44 (93%)
STKc_LKB1 55..309 CDD:271021 235/253 (93%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..331 12/18 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433 16/35 (46%)
stk11NP_001016533.1 STKc_LKB1 58..312 CDD:271021 235/253 (93%)

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