Protein Alignment STK11 and CG17698

DIOPT Version :10

• Sequence 1: NP_000446.1
• Gene: STK11 / 6794
• HGNCID: 11389
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_001036633.2
• Gene: CG17698 / 4379919
• FlyBaseID: FBgn0040056
• Length: 694
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 125/429 - (29%)
• Similarity: 195/429 - (45%)
• Gaps: 107/429 - (24%)

Human    46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL-------RRIPNGEAN----VKKEI 99
            :.:|.:.:.:|:||||.||.....|.....|:|||.||:|       ||.|....:    |.:||
  Fly   280 LNQYRLMEQIGQGSYGLVKLAYSEEDSTHYAMKILSKKRLLRQAGLMRRGPRKATSPLDRVYREI 344

Human   100 QLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEML-----DSVPEKRFPVCQAHGYFCQ 159
            .:|::|.|.||::||:||.:..:..:|||.|....|  |:|     :.:.|||     |...|.:
  Fly   345 AVLKKLDHPNVVKLVEVLDDPLEDSLYMVFELVKQG--EVLRIPTDNPLSEKR-----AWSIFRE 402

Human   160 LIDGLEY------------------LHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAA 206
            .:.||||                  :|.|.|:|.||||||||||..|.:||:||||.   :.|..
  Fly   403 SLLGLEYYTMLSSSAISLKRIFVYTVHHQKIIHADIKPGNLLLTEFGHVKIADLGVC---NEFLG 464

Human   207 DDTC---RTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENI 267
            ||..   .::.|:|||:.|| :..|.:.:.|...|:|:.|.|||::..|..||..|::..|:|.|
  Fly   465 DDATISNGSTAGTPAFRAPETLIPGQNEYCGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKI 529

Human   268 GKGSYAIPGDCGPPLSDLLKG----MLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDT 328
            .:.|...|.:  ..:::.||.    |||..|.:|.:|.|::...|.     .::...|:|    |
  Fly   530 KQDSVKFPEN--HKVTENLKSCIVQMLEKNPTQRITIPQLKTSKWV-----TSDGDYPLP----T 583

Human   329 KDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMN 393
            ::....:..|          :|||:    |.::                      |.:||   ::
  Fly   584 EEENCCLVQV----------DDEDI----DSVV----------------------RSIPK---LD 609

Human   394 GTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQ 432
            .....:...|..:.|   ||..|.||.:|.  .|:.|.:
  Fly   610 TLILIKTMLKKHSFG---NPFVKGCSGTSS--SLAGCSR 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK11	NP_000446.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000269|PubMed:18687677	45..90		18/50 (36%)
		STKc_LKB1	55..309	CDD:271021	102/295 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..331		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..433		10/36 (28%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	103/302 (34%)