Protein Alignment STK11 and Stk11

DIOPT Version :10

• Sequence 1: NP_000446.1
• Gene: STK11 / 6794
• HGNCID: 11389
• Length: 433
• Species: Homo sapiens
• Sequence 2: NP_001101539.1
• Gene: Stk11 / 314621
• RGDID: 1308653
• Length: 436
• Species: Rattus norvegicus
• Alignment Length: 438
• Identity: 394/438 - (89%)
• Similarity: 405/438 - (92%)
• Gaps: 7/438 - (1%)

Human     1 MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKE 65
            |:|.|||.||:|.||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MDVADPQPLGLFPEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKE 65

Human    66 VLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVME 130
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
  Rat    66 VLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVME 130

Human   131 YCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDL 195
            |||||||||||||||||||||||||||.||||||||||||||||||||||||||||.||||||||
  Rat   131 YCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDL 195

Human   196 GVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNI 260
            ||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 GVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNI 260

Human   261 YKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPS 325
            ||||||||:|.:.||.||.|||||||:|||||||||||||||||||||||||||.|||.||||||
  Rat   261 YKLFENIGRGDFTIPCDCAPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPS 325

Human   326 PDTKDRWRSMTVVPYLEDLHG---ADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLP 387
            |||||||||||||||||||||   .:||||||||||.|||||||||||||.|||...|||...||
  Rat   326 PDTKDRWRSMTVVPYLEDLHGRAEEEEDEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLP 390

Human   388 KAVCMNGTEAAQLSTKSRAEGR--APNPARKACSASSKIRRLSACKQQ 433
            ||||:|||| .|||:|.:.|||  |.|||||.|| |:|||||||||||
  Rat   391 KAVCVNGTE-PQLSSKVKPEGRPGAANPARKVCS-SNKIRRLSACKQQ 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK11	NP_000446.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000269|PubMed:18687677	45..90		44/44 (100%)
		STKc_LKB1	55..309	CDD:271021	242/253 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..331		16/18 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..433		25/37 (68%)
Stk11	NP_001101539.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000250	45..90		44/44 (100%)
		STKc_LKB1	55..309	CDD:271021	242/253 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421		15/24 (63%)