DRSC/TRiP Functional Genomics Resources

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Protein Alignment STK11 and par-4

DIOPT Version :10

Sequence 1:NP_000446.1 Gene:STK11 / 6794 HGNCID:11389 Length:433 Species:Homo sapiens
Sequence 2:NP_001366977.1 Gene:par-4 / 180185 WormBaseID:WBGene00003919 Length:617 Species:Caenorhabditis elegans


Alignment Length:409 Identity:156/409 - (38%)
Similarity:223/409 - (54%) Gaps:27/409 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    30 DSTE---VIYQP--RRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89
            |::|   :.::|  ::|..|:|..|:.|..:|.||||||||.:|..||.||||||:|..|||:|.
 Worm   159 DNSEFQHIEFEPIVKQKGPKIIEGYMWGGQIGTGSYGKVKECIDMYTLTRRAVKIMKYDKLRKIT 223

Human    90 NGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH 154
            ||..|::.|:.:|||:.|:|||:|:::.....|.|:|||.|||:..:|::||..|.:|..:.::|
 Worm   224 NGWENIRSEMSILRRMNHRNVIKLIEIFNIPAKGKVYMVFEYCIGSVQQLLDMEPARRLTIGESH 288

Human   155 GYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219
            ..|.:|..||.||||:.:.||||||||||::...|:||.|.||||.::.|..|..|....|:|.|
 Worm   289 AIFIELCQGLNYLHSKRVSHKDIKPGNLLVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKF 353

Human   220 QPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGD--CGPP 281
            |||| |....|.|.|:|.|:|||||||||:.:|.||||...:.||:|.||.....:|.:  ....
 Worm   354 QPPECIYGNHDFFDGYKADMWSAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNVQLTKD 418

Human   282 LSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHG 346
            |.|||..:||.:..:|.:..:...|.||....|..:....|.....|.|  |.:|::..:..|:.
 Worm   419 LQDLLTKLLEKDFNERPTCLETMIHPWFLSTFPEDQGLGRIMERMRTGD--RPLTMLSSMTALYD 481

Human   347 ADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGL----------PKAVCMNGTEAAQLS 401
            ....||...|||::...|.. :|..:..|.....|...|.          |..|..:...||.|.
 Worm   482 GITPEDELIIEDNLGIIQQI-LPINLTSEAVLERGSFPGFKFLEAKPGDGPDGVEGSEDSAAPLG 545

Human   402 TKSRAEGRA------PNPA 414
            .:.|...|:      |.||
 Worm   546 PQRRPSSRSMPTCAPPGPA 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STK11NP_000446.1 Sufficient for interaction with SIRT1. /evidence=ECO:0000269|PubMed:18687677 45..90 26/44 (59%)
STKc_LKB1 55..309 CDD:271021 119/256 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..331 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433 8/24 (33%)
par-4NP_001366977.1 Protein Kinases, catalytic domain 189..446 CDD:473864 119/256 (46%)

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