DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STK10 and BCK1

DIOPT Version :9

Sequence 1:	NP_005981.3	Gene:	STK10 / 6793	HGNCID:	11388	Length:	968	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	295	Identity:	102/295 - (34%)
Similarity:	149/295 - (50%)	Gaps:	37/295 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    17 KRKSREYEHVRRDLDPNEVWEIVGE-LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV 80
            |....||:..        .| :.|| :|.|:||.||...|..||.:.|.|.:|........:.|:
Yeast  1164 KNSKGEYKEF--------AW-MKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAIL 1219

Human    81 --------EIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVV 137
                    |:..|...||..||:.||....:....:.:|:..||:|.:::....| ..||.|:.:
Yeast  1220 STVEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGR-FDEPLIKHL 1283

Human   138 CRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRD-SFIGTPYWMAP 201
            ..|:|:.|.:||||.|:|||:||.|:|:..:|..:::|||:|.|:.......| :..||.:||||
Yeast  1284 TTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAP 1348

Human   202 EVVMCETMKDTP--YDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKI--AKSDPP----TLL 258
            |:|      ||.  |..|.||||||..::||...:.|...|..:..:.||  :||.||    ||.
Yeast  1349 EMV------DTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLP 1407

Human   259 TPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPF 293
            ..|:..   |:||....:.|||.||:|.:||.|||
Yeast  1408 LISQIG---RNFLDACFEINPEKRPTANELLSHPF 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK10	NP_005981.3	STKc_STK10	23..314	CDD:132975	100/289 (35%)
		S_TKc	36..294	CDD:214567	99/276 (36%)
		Activation segment	175..224		22/51 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..411
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..490
		PKK	587..725	CDD:289257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..690
		PKK	755..895	CDD:289257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..929
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..968
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	99/286 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910