DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDKL5 and YGK3

DIOPT Version :10

Sequence 1:NP_003150.1 Gene:CDKL5 / 6792 HGNCID:11411 Length:1030 Species:Homo sapiens
Sequence 2:NP_014513.1 Gene:YGK3 / 853992 SGDID:S000005488 Length:375 Species:Saccharomyces cerevisiae


Alignment Length:337 Identity:97/337 - (28%)
Similarity:158/337 - (46%) Gaps:71/337 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    19 VGEGAYGVVLKCRHKETHEIV-----------AIKKFKDSEENEEVKETTLRELKMLRTLKQENI 72
            :|.|::|.|       |..|:           |||:...|.:.:.:      ||::|:.::..|:
Yeast    47 IGHGSFGTV-------TQSILSSNSIEWLGPYAIKRVVKSPKVQSL------ELEILQNIRHPNL 98

Human    73 VELKEAFRRR------GKLY---LVFEYVEKNM-LELLEEMPNG--VPPEKVKSYIYQLIKAIHW 125
            |.|:..|...      |.||   .|.||:.:.: .|:.|...||  :|.:.:|.|.:|:::|:..
Yeast    99 VTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLT 163

Human   126 CHKNDIVHRDIKPEN-LLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PY 188
            .|...|.|.|:||.| |:|..:.:.|:||||.|:.|.:  |.....|..:|:||:|||||.: .|
Yeast   164 LHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDD--NTELKTYFCSRFYRAPELLLNSKDY 226

Human   189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLP------SEQMKLFYSNPRFHGL 247
            ...:|:||:|||:||:..|||||.|:|...||..|.|:||..|      |::::...::.:|...
Yeast   227 TTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKF 291

Human   248 R--FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR----LLDRS 306
            .  ||::....              ::.:..:|..|..:|....|.:.|..|...|    .|.|.
Yeast   292 MHWFPSIEFFD--------------VEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRG 342

Human   307 PSRSAKRKPYHV 318
            .|     .|.|:
Yeast   343 SS-----MPVHL 349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDKL5NP_003150.1 STKc_CDKL5 11..297 CDD:270838 90/310 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..834
YGK3NP_014513.1 STKc_GSK3 35..332 CDD:271039 91/313 (29%)
Blue background indicates that the domain is not in the aligned region.

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