DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDKL5 and CAK1

DIOPT Version :10

Sequence 1:NP_003150.1 Gene:CDKL5 / 6792 HGNCID:11411 Length:1030 Species:Homo sapiens
Sequence 2:NP_116624.1 Gene:CAK1 / 850515 SGDID:S000001865 Length:368 Species:Saccharomyces cerevisiae


Alignment Length:412 Identity:85/412 - (20%)
Similarity:156/412 - (37%) Gaps:149/412 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    12 KFE--ILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVE 74
            |||  ||..:|.       ||:|     |:.:.:.|.::.|         :|.:|...::.|:.|
Yeast    45 KFEVSILNKLGN-------KCKH-----ILPLLESKATDNN---------DLLLLFPFEEMNLYE 88

Human    75 LKEAFRRRGKLYLVFEYVEKN-MLELLE-EMPNGVPPEKVK------------SYIYQLIKAIHW 125
            ..:...:|.:.       :|| ..:||. .:|....|...|            |:..|:::.|.:
Yeast    89 FMQMHYKRDRR-------KKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAF 146

Human   126 CHKNDIVHRDIKPENLLISHN-----DVLKLCDFGFARNL-------SEGNNANYTEYVATRWYR 178
            .|:|.|:||||||:|:::::|     ..|.:.|||.:.::       :|..::..|: ::|..|:
Yeast   147 LHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTD-ISTGIYK 210

Human   179 SPELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLP------SEQMK 236
            :||:|.|.. |...||:||:..|:.:      .|..|:         ..:|.:|      |:.|.
Yeast   211 APEVLFGVKCYDGGVDVWSLLIIISQ------WFQRET---------SRMGHVPAMIDDGSDDMN 260

Human   237 LFYSNPR-----FHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 296
            ...|:.|     |..|..|::       :::..:.....:|....:...|...:|:.:|      
Yeast   261 SDGSDFRLICSIFEKLGIPSI-------QKWEEVAQHGSVDAFVGMFGADGDGKYVLDQ------ 312

Human   297 FQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSV---GLPRADE 358
                                                          .||:| :|:   .:||.||
Yeast   313 ----------------------------------------------EKDVQ-ISIVERNMPRLDE 330

Human   359 --GLPANESFLNGNLAGASLSP 378
              .:...:.|:|..|...|.||
Yeast   331 IADVKVKQKFINCILGMVSFSP 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDKL5NP_003150.1 STKc_CDKL5 11..297 CDD:270838 71/324 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 3/48 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..834
CAK1NP_116624.1 Protein Kinases, catalytic domain 13..>234 CDD:473864 55/217 (25%)
Protein Kinases, catalytic domain <135..363 CDD:473864 61/294 (21%)
Blue background indicates that the domain is not in the aligned region.

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