Protein Alignment CDKL5 and cdkl5

DIOPT Version :10

• Sequence 1: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Sequence 2: NP_001139240.1
• Gene: cdkl5 / 559341
• ZFINID: ZDB-GENE-081022-110
• Length: 1080
• Species: Danio rerio
• Alignment Length: 1117
• Identity: 600/1117 - (53%)
• Similarity: 735/1117 - (65%)
• Gaps: 222/1117 - (19%)

Human     1 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR 65
            ||||:|||||||||:||:|||||||||||||||||.|:|||||||||||||||||||||||||||
Zfish     1 MKIPDIGNVMNKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLR 65

Human    66 TLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKND 130
            ||||:||||||||||||||||||||||||||||||||:|||..|:||:|||:||||||||||||:
Zfish    66 TLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNE 130

Human   131 IVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMW 195
            ||||||||||||||.||:|||||||||||||||::|||||||||||||||||||||||||:||||
Zfish   131 IVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLGAPYGKAVDMW 195

Human   196 SVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLER 260
            ||||||||||||||||||||||||||||||||||||.||||||||||||.|||||:|:|||:|:|
Zfish   196 SVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDR 260

Human   261 RYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR------LLDRSPSRSAKRKPYHVE 319
            |||||:|.::||||||||.|:|.:|:|||||||||.||..|      :...:|.||:||||||.:
Zfish   261 RYLGIINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTPPRSSKRKPYHGD 325

Human   320 SSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNG-NL-AGASLSP-LHT 381
             :|:.:|:...||:   ||.|:||||..:    |||.::...:.:||||| |: ..::||| ||.
Zfish   326 -NTIPSRSHGSKSS---SHRRANSKDCSS----LPRHEDLHRSTDSFLNGTNMPTSSTLSPTLHP 382

Human   382 KTYQAS--SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPK---PSEGPGT---KYLKSNS 438
            |:|||.  |:..|::|||.|||:|||||||:||.|||||||:.||   .|.|..|   |||||
Zfish   383 KSYQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLGPKVGVASVGMDTSTGKYLKS-- 445

Human   439 RSQQNRH-SFMESSQSKAGTLQPNEKQSRHSYID----TIPQSS---RSPSYRTKAKSHGALSDS 495
             |:|.|| ||:|   .|..|||..:|.|||:|::    ::|.:|   .|.|:.:.:||||||:|:
Zfish   446 -SKQGRHSSFLE---GKTSTLQSGDKHSRHNYMESSHGSMPSTSSSKSSSSFLSLSKSHGALNDA 506

Human   496 KSVSNLSEARAQIAEP-----STSRYFPSSCLDLN-SPTSPTPTRHSDT-RTLLSPSGR-NNRNE 552
            ||||||:|.|..:.:|     |.|||||||||||| :|.||...||:.| |...||||| :||.|
Zfish   507 KSVSNLAETRLHLDDPMAGSGSGSRYFPSSCLDLNAAPGSPRGERHAGTERQGHSPSGRGSNRLE 571

Human   553 -GTLDSRRTTTRHSKTMEELKLPEHMDSS-----HSHSLSAPHESFSYGLGYTSPFSSQQRPHRH 611
             |||||||::.| .||.:|.|..:.:|.|     |:|:|.:||||:.||||||||||||||||||
Zfish   572 GGTLDSRRSSGR-KKTPDEPKPTDTLDPSRAAGGHAHNLPSPHESYPYGLGYTSPFSSQQRPHRH 635

Human   612 SMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQ-------------PGEQLPPEMT----- 658
            ||||.|::.|..|.:.:|.:|||:..||:||||||||             ..|:|.||::
Zfish   636 SMYVRRERHRPHGQENNLVVGQGVPTRASSLQLLSPQLQHRTLPRHNTSSSREELTPELSRNDQS 700

Human   659 -----VARSSVKETSREGTSSFHT-RQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYR 717
                 .:|..:|:::|:.|::||| |.|:|.|:|||.|.:|||:.||||.:|:|.:|||||||||
Zfish   701 PKEKPHSRPLIKDSTRDNTATFHTQRPKNEAGMYHDAHMEDGTSSKENRIIYSDSMPRRVGSFYR 765

Human   718 VPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPEN--ISHSEQLKEKEKQGFF 780
            ||||||||:|.|....:||.::.:|:.:.|||||||..||||.:.|.  ::..|..|:|||||||
Zfish   766 VPSPRPDNTFLETTGQSRVQAVAAENPTMTNHSKRQTNFDPWNNSEAMVMNPPEVPKQKEKQGFF 830

Human   781 RSMKKKKKKSQ-----------------------------------------TVPNSDSPDLLTL 804
            |::||||||||                                         .||:....|.|.|
Zfish   831 RAIKKKKKKSQPTDGNAGRNPSIKKSLFPLFNSKNSLKHNSSVKVLPVVPQPMVPSETQQDQLVL 895

Human   805 QKSIHSASTPSSRPKE--------------------------------WRPEKISDLQTQSQPLK 837
            |:.:.|:|..|||.:.                                |.|||..::|.|:||||
Zfish   896 QRPVKSSSHHSSRHRNRDRERERDMERDRERERDRNRDRDRERDRDNTWPPEKQPEVQPQNQPLK 960

Human   838 SLRKLLHLSS--ASNHP----ASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPK 896
            ||||||||||  .||.|    .|::.|||||....:|.:.:|:|.||....:         |..|
Zfish   961 SLRKLLHLSSPATSNQPPPPDRSAELRFQPLPNPPSKANLNEVRGHPAGSVT---------PNTK 1016

Human   897 GRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNR--------A 953
            .|                                            |||...:|.:        |
Zfish  1017 SR--------------------------------------------KPHNYPLPGQIESSWHVSA 1037

Human   954 LHRPISSPAPYP 965
            |:|  :..||||
Zfish  1038 LNR--AEGAPYP 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	253/285 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349		21/54 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566		110/208 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834		100/286 (35%)
cdkl5	NP_001139240.1	STKc_CDKL5	11..297	CDD:270838	253/285 (89%)