DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CDKL5 and Cdk2

DIOPT Version :10

Sequence 1:NP_003150.1 Gene:CDKL5 / 6792 HGNCID:11411 Length:1030 Species:Homo sapiens
Sequence 2:NP_524420.1 Gene:Cdk2 / 42453 FlyBaseID:FBgn0004107 Length:314 Species:Drosophila melanogaster


Alignment Length:339 Identity:116/339 - (34%)
Similarity:176/339 - (51%) Gaps:41/339 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     9 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIV 73
            :::.|:....:|||.||:|.|.|...|.:.||:||.:...|.|.|..|.:||:.:|:.||..|:|
  Fly     4 ILDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVV 68

Human    74 ELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKP 138
            :|.:.......||::|||:..::.:|:::..:...|:.:|||::|::.|:.:||.|.|:|||:||
  Fly    69 QLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKP 133

Human   139 ENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILG 202
            :|||:.....:||.|||.||..:....| ||..|.|.|||:||:|||.. |...||:||:|||..
  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRA-YTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFS 197

Human   203 ELSDGQPLFPGESEIDQLFTIQKVLG-----------PLPSEQMKLFYSNPRFHGLRFPAVNHPQ 256
            |:...:.||||:||||||:.|.:.|.           .||..:.|.    ||:.|     .|.||
  Fly   198 EMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKF----PRWEG-----TNMPQ 253

Human   257 SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESS 321
            .       |......:|:.::|..||..|...:..|.|..|:..:.:|            ||...
  Fly   254 P-------ITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVD------------HVALP 299

Human   322 TLSNRNQAGKSTAL 335
            ...|...|.:.|.|
  Fly   300 VDPNAGSASRLTRL 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDKL5NP_003150.1 STKc_CDKL5 11..297 CDD:270838 108/297 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..834
Cdk2NP_524420.1 STKc_CDK1_CdkB_like 8..287 CDD:270829 108/295 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.