Protein Alignment CDKL5 and cka1

DIOPT Version :10

• Sequence 1: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Sequence 2: NP_593642.1
• Gene: cka1 / 2541972
• PomBaseID: SPAC23C11.11
• Length: 332
• Species: Schizosaccharomyces pombe
• Alignment Length: 313
• Identity: 91/313 - (29%)
• Similarity: 140/313 - (44%)
• Gaps: 49/313 - (15%)

Human    11 NKFEILGVVGEGAYGVVL---------KCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRT 66
            :.:||:..||.|.|..|.         ||..| ..:.|..||.|             ||:|:|:.
pombe    41 DNYEIIRKVGRGKYSEVFEGLNVLNNSKCIIK-VLKPVKYKKIK-------------REIKILQN 91

Human    67 LK-QENIVELKEAFR--RRGKLYLVFEYVE----KNMLELLEEMPNGVPPEKVKSYIYQLIKAIH 124
            |. ..||:.|.:..|  ......|:||:|:    :.:...|.:.       .::.|.|:|:||:.
pombe    92 LAGGPNIISLLDIVRDPESKTPSLIFEFVDNIDFRTLYPTLSDY-------DIRYYSYELLKALD 149

Human   125 WCHKNDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-AP 187
            :||...|:|||:||.|::|.|.. .|:|.|:|.|.....|  ..|...||:|:::.||||:. ..
pombe   150 FCHSRGIMHRDVKPHNVMIDHKKRKLRLIDWGLAEFYHAG--MEYNVRVASRYFKGPELLVDFRE 212

Human   188 YGKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGP------LPSEQMKLFYSNPRFH 245
            |..|:|:||.|.:...| ......|.|....|||..|.||||.      :...|:.|........
pombe   213 YDYSLDIWSFGVMFAALIFKKDTFFRGRDNYDQLVKIAKVLGTDELFAYVQKYQIVLDRQYDNIL 277

Human   246 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 298
            | ::|..:....:.|....:.|...:||:..||:.|..:|...::.:.||.||
pombe   278 G-QYPKRDWYSFVNRDNRSLANDEAIDLLNRLLRYDHQERLTCQEAMAHPYFQ 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	89/310 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834
cka1	NP_593642.1	STKc_CK2_alpha	24..329	CDD:271034	89/311 (29%)