Protein Alignment CDKL5 and lsk1

DIOPT Version :10

• Sequence 1: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Sequence 2: NP_594393.1
• Gene: lsk1 / 2541672
• PomBaseID: SPAC2F3.15
• Length: 593
• Species: Schizosaccharomyces pombe
• Alignment Length: 289
• Identity: 101/289 - (34%)
• Similarity: 156/289 - (53%)
• Gaps: 2/289 - (0%)

Human    13 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77
            :|.:..:|||.||.|.|..:..|.::||:|:.:..:|.:....||:||:|:|:.|:.:|||.|.|
pombe   277 YEKIDQIGEGTYGKVYKAINTVTGDLVALKRIRLEQEKDGFPITTVREVKILQRLRHKNIVRLLE 341

Human    78 AFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLL 142
            ....:..:|:||||::.::..:|........|..:|....|:.:|:.:.|...::|||||..|:|
pombe   342 IMVEKSSVYMVFEYMDHDLTGVLLNSQLHFTPGNIKHLSKQIFEALAYLHHRGVLHRDIKGSNIL 406

Human   143 ISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APYGKSVDMWSVGCILGELSD 206
            :::|..||..|||.||..:...:||||..|.|.|:|.|||||| ..|..:||:||.|||:.||..
pombe   407 LNNNGDLKFADFGLARFNTSSKSANYTNRVITLWFRPPELLLGETAYDTAVDIWSAGCIVMELFT 471

Human   207 GQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLL 271
            |:|.|.|..||.||..|..::| .|.........|..::.|..|...........:..||:...:
pombe   472 GKPFFQGRDEISQLEVIYDMMG-TPDVHSWPEVKNLPWYELLKPVEEKKSRFVETFKEILSPAAI 535

Human   272 DLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
            ||.:.||.|:|..|....:.|.|..|.::
pombe   536 DLCQKLLALNPFCRPSAHETLMHEYFTSE 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	100/284 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834
lsk1	NP_594393.1	STKc_CDK9_like	277..561	CDD:270832	100/284 (35%)