DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDKL5 and cdk9

DIOPT Version :10

Sequence 1:NP_003150.1 Gene:CDKL5 / 6792 HGNCID:11411 Length:1030 Species:Homo sapiens
Sequence 2:NP_595616.1 Gene:cdk9 / 2540239 PomBaseID:SPBC32H8.10 Length:591 Species:Schizosaccharomyces pombe


Alignment Length:591 Identity:163/591 - (27%)
Similarity:249/591 - (42%) Gaps:87/591 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVE 74
            :..:.::..:|||.:|.|.|.:.::..::.|:|:.....|.|....|.:||:|:|:::|.|||:.
pombe    33 LTDYHLMEKLGEGTFGEVYKSQRRKDGKVYALKRILMHTEKEGFPITAIREIKILKSIKHENIIP 97

Human    75 LKE--------AFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDI 131
            |.:        ..||||.:|:|..|::.::..|||.........::|.|:.||.....:.|...|
pombe    98 LSDMTVVRADKKHRRRGSIYMVTPYMDHDLSGLLENPSVKFTEPQIKCYMKQLFAGTKYLHDQLI 162

Human   132 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNAN------------YTEYVATRWYRSPELLL 184
            :|||:|..||||.::.:||:.|||.||.::|.:.||            ||..|.|||||||||||
pombe   163 LHRDLKAANLLIDNHGILKIADFGLARVITEESYANKNPGLPPPNRREYTGCVVTRWYRSPELLL 227

Human   185 G-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
            | ..|..::||||||||:.|:..|:|:..|.|::|||..|.::.|......|..:...|...|:|
pombe   228 GERRYTTAIDMWSVGCIMAEMYKGRPILQGSSDLDQLDKIFRLCGSPTQATMPNWEKLPGCEGVR 292

Human   249 -FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT------------- 299
             ||  :||::||..:. .....:..|...:|.|:|.:|......|.|..|.|             
pombe   293 SFP--SHPRTLETAFF-TFGKEMTSLCGAILTLNPDERLSASMALEHEYFTTPPYPANPSELQSY 354

Human   300 --QRLLDRSPSRSAKRKPYHVESSTLSNRNQ-----AGKSTALQSHHRSNSKDIQNLSVGLPRAD 357
              ....|:...|..:....|....|.:.:.|     .|.|.......|.|..       ..|:..
pombe   355 SASHEYDKRRKREQRDANSHAFEQTANGKRQFRFMTRGPSDPWYGIRRPNYN-------SQPQYQ 412

Human   358 EGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID 422
            .|        :.|..|.::.......||...|  ...|.||::     |..|.::.......|..
pombe   413 RG--------SYNREGGNMDRSRNVNYQPKRQ--QNFKPLTSD-----LPQKNSEFSETNAMNQT 462

Human   423 PKPSEGPGTKYLK-SNSRSQQNRH------SFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
            ...|...|.:|.: ...|||:.|:      ...:||||:......:.:...:|.:.|..::|.:.
pombe   463 SNHSHADGQRYYRPEQDRSQRLRNPSDYGRQGRQSSQSQQPAWNVSSRYQNNSKVQTTSRASENA 527

Human   481 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPS 545
            .  |....|........|...|.|| |.|...|:...|||          |......|..|.|||
pombe   528 D--TNKTQHNIKYIDSYVPEYSIAR-QSANQKTNEQHPSS----------TSLHQQSTSDLKSPS 579

Human   546 GRNNRN 551
            ...|.|
pombe   580 FHENSN 585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDKL5NP_003150.1 STKc_CDKL5 11..297 CDD:270838 105/307 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 9/53 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..566 43/177 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..834
cdk9NP_595616.1 STKc_BUR1 27..339 CDD:270849 105/308 (34%)
Blue background indicates that the domain is not in the aligned region.

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