Protein Alignment CDKL5 and pef1

DIOPT Version :10

• Sequence 1: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Sequence 2: NP_587921.1
• Gene: pef1 / 2539366
• PomBaseID: SPCC16C4.11
• Length: 288
• Species: Schizosaccharomyces pombe
• Alignment Length: 314
• Identity: 112/314 - (35%)
• Similarity: 172/314 - (54%)
• Gaps: 51/314 - (16%)

Human    10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK-DSEENEEVKETTLRELKMLRTLKQENIV 73
            || ::.|..:|||.|..|.|.:::.|.||||:|..: |::|.  ...|.:||:.:::.|:..||:
pombe     1 MN-YQRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEG--TPSTAIREISLMKELRHPNIM 62

Human    74 ELKEAFRRRGKLYLVFEYVEKNMLELLEEMPN--GVPPEKVKSYIYQLIKAIHWCHKNDIVHRDI 136
            .|.:..:...||.|||||:||::.:.::...|  .:||.:||::..||:|.|.:||:|.::|||:
pombe    63 SLSDVLQTENKLMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGISFCHENRVLHRDL 127

Human   137 KPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVDMWSVGCI 200
            ||:||||:....|||.|||.||::....| .::..|.|.|||:|::|||: .|..|:|:||||||
pombe   128 KPQNLLINSRGELKLADFGLARSIGIPVN-TFSNEVVTLWYRAPDVLLGSRVYSTSIDIWSVGCI 191

Human   201 LGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQ--------------------MKLFYSNPRFH 245
            :.|::.|:|||.|.:..|||..|.::|| .|:||                    ..|.|..|.|.
pombe   192 MAEMATGRPLFAGSNNEDQLLKIFRLLG-TPTEQSWPGISLLPEYKPTFPIYKAQDLAYLFPTFD 255

Human   246 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
            .|.                      |||::.:|:|.|..|...:..|.|..|.|
pombe   256 PLG----------------------LDLLRRMLRLQPELRTTGQDALQHAWFLT 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	109/309 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349		112/314 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834
pef1	NP_587921.1	Protein Kinases, catalytic domain	2..285	CDD:473864	109/309 (35%)