DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDKL5 and cdk-11.2

DIOPT Version :10

Sequence 1:NP_003150.1 Gene:CDKL5 / 6792 HGNCID:11411 Length:1030 Species:Homo sapiens
Sequence 2:NP_509746.2 Gene:cdk-11.2 / 181247 WormBaseID:WBGene00013917 Length:668 Species:Caenorhabditis elegans


Alignment Length:369 Identity:124/369 - (33%)
Similarity:189/369 - (51%) Gaps:65/369 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK---QEN 71
            ::::.||.|:.||.||.|.:.::..|.|:||:|:||..:|.|....|.|||:.||  ||   .||
 Worm   301 ISEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINML--LKAGAHEN 363

Human    72 IVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKV---KSYIYQLIKAIHWCHKNDI 131
            ||.:||..  ..:.::|:..||||.::..|:::|.:.....|.   |:.:.||:..|...||..|
 Worm   364 IVNVKEILVGSTKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGIEHMHKLWI 428

Human   132 VHRDIKPENLLISHNDVLKLCDFGFARNLSEGNN----ANYTEYVATRWYRSPELLL-GAPYGKS 191
            :|||:|..||||||:.:||:.|||.||...|..:    ...|..|.|.||||||||| ...|...
 Worm   429 LHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTP 493

Human   192 VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQ-------MKLFYSNPRFHGLRF 249
            |||||:|||:.|....:|:|.|:||.:|:..|.:::| .|:||       :|:      ::.:.|
 Worm   494 VDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMG-TPTEQIWPDIKELKV------WNMVEF 551

Human   250 PAVNHPQSLERRYLG--ILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF--------------- 297
            |.|. |..|.|.:.|  ::|....||:..:|.|:||:|....:.|.|..|               
 Worm   552 PPVK-PGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSEHPKAVPPEDLPVY 615

Human   298 -----------QTQR-------LLDRSPSRSAKRKPYHVESSTL 323
                       :.:|       |.|..|.|:|..:.::|::..|
 Worm   616 PAKSELNAAPPENRRKNRLEALLADEEPERAALLRQFNVKAEQL 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDKL5NP_003150.1 STKc_CDKL5 11..297 CDD:270838 115/307 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..834
cdk-11.2NP_509746.2 Protein Kinases, catalytic domain 298..600 CDD:473864 115/308 (37%)
Blue background indicates that the domain is not in the aligned region.

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