Protein Alignment CDKL5 and cdkl5

DIOPT Version :10

• Sequence 1: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Sequence 2: XP_031752565.1
• Gene: cdkl5 / 100145195
• XenbaseID: XB-GENE-951076
• Length: 1022
• Species: Xenopus tropicalis
• Alignment Length: 1090
• Identity: 698/1090 - (64%)
• Similarity: 799/1090 - (73%)
• Gaps: 140/1090 - (12%)

Human     1 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR 65
            |||||:||||||||:||||||||||||||||||||.|||||||||||||||||||||||||||||
 Frog     1 MKIPNLGNVMNKFEVLGVVGEGAYGVVLKCRHKETKEIVAIKKFKDSEENEEVKETTLRELKMLR 65

Human    66 TLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKND 130
            |||||||||||||||||||||||||||||||||||||||||||||||.:||||||||||||||||
 Frog    66 TLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVTNYIYQLIKAIHWCHKND 130

Human   131 IVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMW 195
            ||||||||||||||:||||||||||||||||||:||||||||||||||||||||||||||:||||
 Frog   131 IVHRDIKPENLLISYNDVLKLCDFGFARNLSEGSNANYTEYVATRWYRSPELLLGAPYGKAVDMW 195

Human   196 SVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLER 260
            ||||||||||||||||||||||||||||||||||||:||||||||||||||:|||||||||||||
 Frog   196 SVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGMRFPAVNHPQSLER 260

Human   261 RYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDR---SPSRSAKRKPYHVESST 322
            |||||::|||||||||||||:|:||:||||.||||.|||||||||   |||||:|||.:|.||:
 Frog   261 RYLGIISSVLLDLMKNLLKLNPSDRFLTEQSLNHPAFQTQRLLDRGGTSPSRSSKRKTHHSESN- 324

Human   323 LSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSP-LHTKTYQA 386
            |::|.|:.||:::|.||||||||.|.||||..|.:|..|.||:|:||.....|.|| :|.|   .
 Frog   325 LASRKQSSKSSSVQPHHRSNSKDTQTLSVGPKRNEETHPPNETFINGAHPAGSHSPTVHQK---K 386

Human   387 SSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESS 451
            :||.||.:||..:||:|||||||:||||.||||:.:.|.|:.||.||.|||||||.|||||||
 Frog   387 NSQSGSGNKDPASNNLPHLLSPKDAKSKNEFDFSPEQKTSDVPGAKYTKSNSRSQHNRHSFME-- 449

Human   452 QSKAGTLQPNEKQSRHSYIDTIPQSS-RSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSR 515
             .|.|:.||:||.:|||||||||||| :|.||...:|:||.|:|||||.||||||.||.||: ||
 Frog   450 -GKTGSWQPSEKHTRHSYIDTIPQSSKKSSSYMNYSKNHGVLTDSKSVGNLSEARGQILEPN-SR 512

Human   516 YFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSS 580
            ||||||.||||||||...||.|:|.:||||||.||.||||:|||.||:||:||||||||:.||||
 Frog   513 YFPSSCHDLNSPTSPAAPRHGDSRGMLSPSGRTNRKEGTLESRRPTTKHSRTMEELKLPDQMDSS 577

Human   581 HSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLL 645
            |||||||||||||||||||||||||||||||||||:||:||.||.|.:|::|||||:||:|||||
 Frog   578 HSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRVKGTDAALNVGQGMASRASSLQLL 642

Human   646 SPQ-----------------------PGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYH 687
            |||                       .|:|:|.|:|.:|:..|:.:|:|.:|||||||:|||.||
 Frog   643 SPQVQHRTLTRSVGSSREDCTEDTTRQGDQVPSEVTHSRTLAKDPNRDGAASFHTRQKTEGGPYH 707

Human   688 DPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKR 752
            |.|.|||.|.|||||:|:|.||||||||||||||||:.:||:|.||:|.||.|.:||..||||||
 Frog   708 DSHPDDGAASKENRHIYSDTVPRRVGSFYRVPSPRPEGTFHDNTVSSRGSSHPVDSSGVTNHSKR 772

Human   753 QPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQT------------------------- 792
            |..||.|...|. |||||:||||||||||.:|||||||||
 Frog   773 QTTFDHWTGAEK-SHSEQMKEKEKQGFFRVIKKKKKKSQTTDSNDPEKPRLKKSLFPLFSSKNHL 836

Human   793 ----------------VPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRK 841
                            :|::|..|.|.:||.:||:|..|||.|||||:|::::.:.|||||||.|
 Frog   837 KRSSSLKKLPVVSLPMMPSADGQDHLPVQKGVHSSSHKSSRQKEWRPDKMAEIHSHSQPLKSLWK 901

Human   842 LLHLSSASNHPASSDPRFQPLTAQQTKN-SFSEIRIHPLSQASGGSSNI-RQEPAPKGRPALQLP 904
            |||.||:||||...|||||||..|..|. ||.|.||||:.|.|.....: ||:|.||.|..||:|
 Frog   902 LLHPSSSSNHPMPPDPRFQPLPNQPPKTPSFPEARIHPVGQTSSSGGVVHRQDPQPKSRQGLQIP 966

Human   905 DGGCDGRRQR-HHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQ 968
                 |:.:. .|..|                                  |:|..:..||:|
 Frog   967 -----GQAEAVWHVSP----------------------------------LNRGTNEGAPFP--- 989

Human   969 VRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAAL 1018
                           |..:..|.|:|..|  ....|..|.:...:.:.||
 Frog   990 ---------------DQLASKTGQNGLPF--NRTKRTRLPNLNDLKETAL 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	270/285 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349		32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566		122/184 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834		117/251 (47%)
cdkl5	XP_031752565.1	STKc_CDKL5	11..297	CDD:270838	270/285 (95%)