Protein Alignment AURKA and IPL1

DIOPT Version :10

• Sequence 1: NP_001411347.1
• Gene: AURKA / 6790
• HGNCID: 11393
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_015115.1
• Gene: IPL1 / 855892
• SGDID: S000006130
• Length: 367
• Species: Saccharomyces cerevisiae
• Alignment Length: 362
• Identity: 151/362 - (41%)
• Similarity: 214/362 - (59%)
• Gaps: 20/362 - (5%)

Human    71 LPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNN---TQKS 132
            |..||...:....|:.|....|.:.     ||.|.|....     :.:|.||...||.   ..|.
Yeast    11 LNANSPSKKTTTRPNTSRINKPWRI-----SHSPQQRNPN-----SKIPSPVREKLNRLPVNNKK 65

Human   133 KQPLPSAPENNPEEELASKQKNEESKK----RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFIL 193
            ...:.|:...:|..:..|.:...|:||    :..:|:|||:|:.|||||||.||..|.:.:.:|.
Yeast    66 FLDMESSKIPSPIRKATSSKMIHENKKLPKFKSLSLDDFELGKKLGKGKFGKVYCVRHRSTGYIC 130

Human   194 ALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 258
            ||||:.|.::.|..::.|.|||||||:.|.|||:.:.||||||..||||::||...|.:|:.|:.
Yeast   131 ALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRL 195

Human   259 LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTT 322
            ...|::...:.||.::||||.|.|.|.:|||||||||:|:|....:|:.||||| ::.|.:||.|
Yeast   196 HGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSIINPPENRRKT 260

Human   323 LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVT 387
            :|||:|||.|||:|.|.:|..:|.|:||||.:|.|.|.||||......|||||:.::...|..::
Yeast   261 VCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSNIS 325

Human   388 EGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKP 424
            :.|:|||.:|||::|..|..|.:|..||||..|  ||
Yeast   326 QDAQDLILKLLKYDPKDRMRLGDVKMHPWILRN--KP 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AURKA	NP_001411347.1	STKc_Aurora-A	161..418	CDD:271018	125/257 (49%)
IPL1	NP_015115.1	STKc_Aurora	118..356	CDD:270909	113/237 (48%)