DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AURKA and aurka

DIOPT Version :9

Sequence 1:	XP_016883523.1	Gene:	AURKA / 6790	HGNCID:	11393	Length:	437	Species:	Homo sapiens
Sequence 2:	NP_001003640.1	Gene:	aurka / 445246	ZFINID:	ZDB-GENE-040801-161	Length:	405	Species:	Danio rerio

Alignment Length:	406	Identity:	244/406 - (60%)
Similarity:	289/406 - (71%)	Gaps:	28/406 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    32 SGIMDRSKENC-ISGPVKATAPVGGPKRVLVTQ--QFPCQNPLPVNSGQAQ----------RVLC 83
            ||...:|..:. |..|........|||||.|||  |.|..||.....|.||          :..|
Zfish     3 SGARSKSSRDLKIHRPENEKVSAAGPKRVPVTQSVQKPVSNPHTRVLGAAQGPQRVQRPVGKTSC 67

Human    84 PSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNT-QKSKQPLPSAPENNPEEE 147
            |.:.:.| |.|       |||..:.|.:.      ..|:|...|.| :.|||..|....::....
Zfish    68 PGDQNTR-PEQ-------HKPAAHSKPQP------KPPLSAETNKTAEPSKQDKPHQTPSSTTST 118

Human   148 LASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQL 212
            .::...:.:|.|:.|.||:|:|||.|||||||:||||||:|:|||||||||||.|||||||||||
Zfish   119 SSNTSGSSKSSKKAWTLENFDIGRALGKGKFGSVYLAREQQTKFILALKVLFKKQLEKAGVEHQL 183

Human   213 RREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 277
            |||||||||||||||||||||||||.|||||||:||.|.:|.|||:...||:||:||||.|||:|
Zfish   184 RREVEIQSHLRHPNILRLYGYFHDAARVYLILEFAPKGELYGELQRCGTFDDQRSATYIMELADA 248

Human   278 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDE 342
            |.|||||.||||||||||||||:.|||||||||||||.|||||:||||||||||||||||:.|||
Zfish   249 LRYCHSKAVIHRDIKPENLLLGANGELKIADFGWSVHTPSSRRSTLCGTLDYLPPEMIEGKTHDE 313

Human   343 KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 407
            |||||||||||||||||:||||..:::|||::|||||||:|..|:.|:||||:|||||||..|..
Zfish   314 KVDLWSLGVLCYEFLVGRPPFETKSHEETYRKISRVEFTYPAHVSNGSRDLINRLLKHNPMHRLP 378

Human   408 LREVLEHPWITANSSK 423
            ::.|:||||:..||:|
Zfish   379 IQGVMEHPWVVENSTK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AURKA	XP_016883523.1	None
aurka	NP_001003640.1	STKc_Aurora-A	132..389	CDD:271018	202/256 (79%)
aurka	NP_001003640.1	S_TKc	138..388	CDD:214567	198/249 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327723
Domainoid	1	1.000	418	1.000	Domainoid score	I4209
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2670
Inparanoid	1	1.050	461	1.000	Inparanoid score	I7021
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265620at7742
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		oto46267
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.300