Protein Alignment AURKA and aurA

DIOPT Version :9

• Sequence 1: XP_016883523.1
• Gene: AURKA / 6790
• HGNCID: 11393
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_476749.1
• Gene: aurA / 41446
• FlyBaseID: FBgn0000147
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 412
• Identity: 199/412 - (48%)
• Similarity: 265/412 - (64%)
• Gaps: 38/412 - (9%)

Human    37 RSKENCISG-PVKATAPVGGPKRVLVTQQ------FPCQNPLPVNSGQAQRV--LCPSNSSQRIP 92
            |.|||.... |.|:.|.....|.:|:.::      .|...|||.:||...|.  |..|||
  Fly    10 RPKENAPHRMPEKSAAVHNMQKNLLLGKKPNSENMAPASKPLPGSSGALIRKPGLGGSNS----- 69

Human    93 LQAQKLVSS-----HKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEEL---- 148
                 :.||     .||:....:|.....:.|.||: |:...:...:..|:|..:...:||
  Fly    70 -----IASSEGNNFQKPMVPSVKKTTSEFAAPAPVA-PIKKPESLSKQKPTAASSESSKELGAAS 128

Human   149 --ASKQKNE-----ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA 206
              |.|:|.:     :..|:.|.|.:|:|||.||:||||||||||||:|:|::|||||||.|:.::
  Fly   129 SSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGES 193

Human   207 GVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL--QKLSKFDEQRTAT 269
            .||||:|||:|||||||||:|||||.||||..|:||||||||.||::..|  |.:.:|||:::||
  Fly   194 NVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSAT 258

Human   270 YITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 334
            ||..|.:||.|.|.:.:|||||||||||||..|.|||||||||||.|:|.|.|||||:|||||||
  Fly   259 YIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEM 323

Human   335 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 399
            ::|:.|.:.||||||||||:|.|||..||.:..|.||||:|.:|::..|:.:::.|..|||:||.
  Fly   324 VQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLV 388

Human   400 HNPSQRPMLREVLEHPWITANS 421
            .||..|..|.:|:.||||.|::
  Fly   389 LNPQHRLPLDQVMVHPWILAHT 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AURKA	XP_016883523.1	None
aurA	NP_476749.1	STKc_Aurora	153..407	CDD:270909	158/253 (62%)
		S_TKc	154..406	CDD:214567	157/251 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145652
Domainoid	1	1.000	336	1.000	Domainoid score	I1120
eggNOG	1	0.900	-	-		E1_KOG0580
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2670
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2178
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D318112at33208
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		otm40694
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	O	PTHR24350
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.800