Protein Alignment AURKA and aurB

DIOPT Version :10

• Sequence 1: NP_001411347.1
• Gene: AURKA / 6790
• HGNCID: 11393
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_477336.1
• Gene: aurB / 34504
• FlyBaseID: FBgn0024227
• Length: 329
• Species: Drosophila melanogaster
• Alignment Length: 335
• Identity: 145/335 - (43%)
• Similarity: 217/335 - (64%)
• Gaps: 20/335 - (5%)

Human   109 KQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENN--PEEELASKQKNEES--KKRQWALEDFEI 169
            :.|......:||.:::              .||.:  |.:.:..|..:.::  :...|:..|||:
  Fly     5 RAKHANRNHLPHLLAK--------------VPEEHQEPIKNMCLKMMSHDAYGQPYDWSPRDFEM 55

Human   170 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF 234
            |..||:||||.||||||:.|.:::|:||:||.:|.|..|:.|:.||:||||.|:||:||||..:|
  Fly    56 GAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWF 120

Human   235 HDATRVYLILEYAPLGTVYRELQKL--SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 297
            ||.:|:||.||.|..|.:::.|:..  .:|||.|:|.|..::||||:|||...|||||:||||:|
  Fly   121 HDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENIL 185

Human   298 LGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP 362
            |.|..:||:||||||.|.|:::|.|||||||||||||::|..:|:.||.|.||:|||||:||.||
  Fly   186 LTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPP 250

Human   363 FEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNC 427
            ||:|:.:.||.:|.|:|.::|..:::|.::||..||:.....|..|.:|:.|.|:.|..::....
  Fly   251 FESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKAGMAERELQ 315

Human   428 QNKESASKQS 437
            ..|....|::
  Fly   316 LQKRERGKEN 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AURKA	NP_001411347.1	STKc_Aurora-A	161..418	CDD:271018	135/258 (52%)
aurB	NP_477336.1	STKc_Aurora	52..306	CDD:270909	134/253 (53%)