DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AURKA and Aurka

DIOPT Version :9

Sequence 1:	XP_016883523.1	Gene:	AURKA / 6790	HGNCID:	11393	Length:	437	Species:	Homo sapiens
Sequence 2:	NP_035627.1	Gene:	Aurka / 20878	MGIID:	894678	Length:	417	Species:	Mus musculus

Alignment Length:	435	Identity:	338/435 - (77%)
Similarity:	362/435 - (83%)	Gaps:	20/435 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     4 SAQGEVGLAGKAHACPSLISFIWTKHVKSGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQ 68
            :.:||.|      .|..:...:|    :.|.|||.||||:|.|||.|.|. ||||||||:|.|.|
Mouse     2 AVEGEPG------CCKRIGKAVW----RRGDMDRCKENCVSRPVKTTVPF-GPKRVLVTEQIPSQ 55

Human    69 NPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSK 133
            |....:|||||||||||| |||:|.|||||.:..||.    .|||.|.|||.|||| |||.||::
Mouse    56 NLGSASSGQAQRVLCPSN-SQRVPSQAQKLGAGQKPA----PKQLPAASVPRPVSR-LNNPQKNE 114

Human   134 QPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVL 198
            |  |:|..|:.|:|.||.||.|::|||||.||||:||||||||||||||||||:|||||||||||
Mouse   115 Q--PAASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVL 177

Human   199 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD 263
            ||.|||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   178 FKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD 242

Human   264 EQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLD 328
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||:|||||
Mouse   243 EQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLD 307

Human   329 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDL 393
            |||||||||||||||||||||||||||||||.|||||:||||||:||||||||||||||||||||
Mouse   308 YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDL 372

Human   394 ISRLLKHNPSQRPMLREVLEHPWITANSSK-PSNCQNKESASKQS 437
            ||||||||.|||..|.||||||||.||||| |:...:||..||.|
Mouse   373 ISRLLKHNASQRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AURKA	XP_016883523.1	None
Aurka	NP_035627.1	STKc_Aurora-A	140..396	CDD:271018	241/255 (95%)
Aurka	NP_035627.1	S_TKc	146..396	CDD:214567	236/249 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954893
Domainoid	1	1.000	484	1.000	Domainoid score	I8254
eggNOG	1	0.900	-	-		E1_KOG0580
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2670
Inparanoid	1	1.050	640	1.000	Inparanoid score	I10050
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000946
OrthoInspector	1	1.000	-	-		oto125029
orthoMCL	1	0.900	-	-		OOG6_100573
Panther	1	1.100	-	-	LDO	PTHR24350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12159
SonicParanoid	1	1.000	-	-		X555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.320