Protein Alignment STK4 and KIC1

DIOPT Version :10

• Sequence 1: NP_006273.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 451
• Identity: 149/451 - (33%)
• Similarity: 226/451 - (50%)
• Gaps: 55/451 - (12%)

Human    16 KLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI---------- 70
            ::|..||.|:.|.:       |.|.:|.|||..:.:||::.|||.:.::||..|:
Yeast    16 EMDVSSLFKRTEVI-------GRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFL 73

Human    71 --IKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQST 133
              :|:||        ::.:|||||.|:|.|||:||:|..||:..:  ||...:.|..|..|::..
Yeast    74 ASLKQIS--------NITRYYGSYLKDTSLWIIMEHCAGGSLRSL--LRPGKIDEKYIGVIMREL 128

Human   134 LKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE 198
            |..|:.:|....|||||||.|:|:..||:.||.|||||.|:..|..:|.|:.|||:|||||||.|
Yeast   129 LVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIME 193

Human   199 -IGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262
             :.|:...||||||||..|:|.|.|||.|:..:||:.:|..:.||.. :...:|.:..:|:..||
Yeast   194 GVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRL-EDRSYSTSLKEFIALCL 257

Human   263 VKSPEQRATATQLLQHPFVRSAKG--VSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEM 325
            .:.|::|.:|..||:..|:|:.|.  .|||::||:..:..:.|.:...:.|....:.|.|:..|.
Yeast   258 DEDPKERLSADDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEA 322

Human   326 DSGTMVRAVGDEMGTVRVAST------MTDGANTMIEHDDTLPSQLGTMVIN------AEDEEEE 378
            ...:. ...||| ....:||.      :.:|...|....|:|.|....:..|      |||..|.
Yeast   323 PKPSQ-NGGGDE-AQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAEDNNEW 385

Human   379 GTMKRRDETMQPAKPSFLEYFEQKEKEN------QINSFGKSVPGPLKNSSDWKIPQDGDY 433
            .|.:.  :....|.|....|:......|      |..:.||..||.:..:|....|...:|
Yeast   386 ATAQH--DLFNYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNY 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK4	NP_006273.1	STKc_MST1_2	26..281	CDD:132943	104/267 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..332		5/28 (18%)
		SARAH_MST1	432..480	CDD:439181	1/2 (50%)
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	115/291 (40%)