Protein Alignment STK4 and Pak

DIOPT Version :10

• Sequence 1: NP_006273.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_001138013.2
• Gene: Pak / 44039
• FlyBaseID: FBgn0267698
• Length: 840
• Species: Drosophila melanogaster
• Alignment Length: 307
• Identity: 123/307 - (40%)
• Similarity: 186/307 - (60%)
• Gaps: 12/307 - (3%)

Human     3 TVQLRNPPRRQLKKLDEDSLTK--------QPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIK 59
            |...|....::.|..||:.|.|        .|...:..:||:|:|:.|:||.||...||..||||
  Fly   531 TPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIK 595

Human    60 QVPVESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLT 122
            |:.:....::  ||.||.:|::...|:||.|..||..:.:||:||||...||::|::  ....:.
  Fly   596 QMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV--TETCMD 658

Human   123 EDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGT 187
            |.:||.:.:..|:.||:||..:.||||||:.||||..:|..||.|||...|::...:||.|::||
  Fly   659 EGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGT 723

Human   188 PFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSD 252
            |:||||||:....|....|:|||||.||||.||:|||.:.:|::|:::|.||..|..::.:..|.
  Fly   724 PYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSS 788

Human   253 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMD 299
            .|.||:.|||....::||:|..||:|||::.|:.::.|..||..|.:
  Fly   789 AFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK4	NP_006273.1	STKc_MST1_2	26..281	CDD:132943	110/256 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..332
		SARAH_MST1	432..480	CDD:439181
Pak	NP_001138013.2	PBD	83..139	CDD:395634
		STKc_PAK_I	558..818	CDD:270814	111/261 (43%)