Protein Alignment STK4 and Mkk4

DIOPT Version :10

• Sequence 1: NP_006273.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_477353.1
• Gene: Mkk4 / 41020
• FlyBaseID: FBgn0024326
• Length: 424
• Species: Drosophila melanogaster
• Alignment Length: 303
• Identity: 95/303 - (31%)
• Similarity: 162/303 - (53%)
• Gaps: 33/303 - (10%)

Human    31 DVLE---KLGEGSYGSVYKAIHKETGQIVAIKQVPV---ESDLQEIIKEIS-IMQQCDSPHVVKY 88
            |.||   ::|.|::|:|.|...|:..:::|:|::..   |.:.::::.::. :|:..:..::|::
  Fly   120 DDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQF 184

Human    89 YGSYFKNTDLWIVMEYCGAG---SVSDIIRLRNKTLTEDEIATILQSTLKGLEYL-HFMRKIHRD 149
            ||:.||..|.||.||.....   ....|...:.:.:.|..:|.|..:|:..|.|| ..::.||||
  Fly   185 YGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRD 249

Human   150 IKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVADIWSLG 211
            :|..||||:..|..||.|||::|||.|::||.......|: ||||.|   :..||:..:|:||||
  Fly   250 VKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERIDPERAKGYDVRSDVWSLG 313

Human   212 ITAIEMAEGKPPYADIHPMRAIF-----MIPTNPP---PTFRKPELWSDNFTDFVKQCLVKSPEQ 268
            ||.:|:|.|..||   ....::|     ::...||   .::...| :|..|.|||..||:|....
  Fly   314 ITLMEVATGNFPY---RKWDSVFEQLCQVVQGEPPRLLTSYNGME-FSKEFVDFVNTCLIKKESD 374

Human   269 RATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQRE 311
            |...::||:.||:|  :|.:...|:.....|:    .||.:::
  Fly   375 RPKYSRLLEMPFIR--RGETSHTDVAVYVADI----LESMEKD 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK4	NP_006273.1	STKc_MST1_2	26..281	CDD:132943	88/271 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..332		2/9 (22%)
		SARAH_MST1	432..480	CDD:439181
Mkk4	NP_477353.1	PKc_MKK4	115..405	CDD:270790	93/295 (32%)