DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STK4 and stk4

DIOPT Version :9

Sequence 1:	XP_005260587.1	Gene:	STK4 / 6789	HGNCID:	11408	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_989249.1	Gene:	stk4 / 394860	XenbaseID:	XB-GENE-955920	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	477	Identity:	367/477 - (76%)
Similarity:	415/477 - (87%)	Gaps:	4/477 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    28 RQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISI 92
            |.||||.|:||.||||||||||||||||||||||||.||||.|||||||:|||||||||||||:|
Frog    12 RHLKKLSEESLNKQPEEVFDVLEKLGEGSYGSVYKASHKETSQIVAIKQIPVESDLQEIIKEIAI 76

Human    93 MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLH 157
            ||||||.||||||||||||||||||||:||.||:|||||||.:||.|||.|||||||||||||||
Frog    77 MQQCDSLHVVKYYGSYFKNTDLWIVMEFCGGGSISDIIRLRKQTLKEDETATILQSTLKGLEYLH 141

Human   158 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 222
            |||||||||||||||||:||.||||||||||||||||||||||||||||||||||||||||||||
Frog   142 FMRKIHRDIKAGNILLNSEGTAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVAD 206

Human   223 IWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRAT 287
            |||||||||||||||||||:|||||||||||:|||||||||||||.:|.||:..||||:||.|::
Frog   207 IWSLGITAIEMAEGKPPYAEIHPMRAIFMIPSNPPPTFRKPELWSKDFVDFINLCLVKNPELRSS 271

Human   288 ATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 352
            ||:||||||:::|||.||||.|||||.|.||||.|.:||||:.::|||::|||.|.||||:|...
Frog   272 ATELLQHPFIKTAKGESILRHLINEAQDAKLKRTELKQREVEPEEEENADEDEADVGTMVQAGSK 336

Human   353 EMGTVRVASTMTDGAN-TMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFE 416
            ::.|::..|||.:.|: ||:| .|.|.:|:|||:||.|||||.||||:..|.:||||||||||||
Frog   337 DLNTMKEFSTMNEAADCTMVE-KDKLNTQMGTMLINDEDEEETGTMKQCTEPVQPAKPSFLEYFE 400

Human   417 QKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQK 481
            |  ||||..:..|:.|.|..:.|:||||.:|||.|||.|:|.:||.||.:||||||||||||..|
Frog   401 Q--KENQFGTPEKTTPAPSTDPSEWKIPLNGDYSFLKDWSVTELQLRLNSLDPMMEQEIEEIHHK 463

Human   482 YQSKRQPILDAIEAKKRRQQNF 503
            ||:||||||:|||:||||||||
Frog   464 YQAKRQPILEAIESKKRRQQNF 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK4	XP_005260587.1	STKc_MST1_2	42..297	CDD:132943	227/254 (89%)
		S_TKc	46..297	CDD:214567	223/250 (89%)
		Mst1_SARAH	449..496	CDD:288481	34/46 (74%)
stk4	NP_989249.1	STKc_MST1_2	26..281	CDD:132943	227/254 (89%)
stk4	NP_989249.1	Mst1_SARAH	431..478	CDD:314497	34/46 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I19174
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55965
Inparanoid	1	1.050	755	1.000	Inparanoid score	I4860
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125295at32523
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm54129
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1715
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.070