Protein Alignment STK4 and hpo

DIOPT Version :10

• Sequence 1: NP_006273.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_611427.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 643
• Identity: 299/643 - (46%)
• Similarity: 370/643 - (57%)
• Gaps: 175/643 - (27%)

Human    13 QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIM 77
            :||||.|:||.:.||:|||::.|||||||||||||:|||:..|||||.|||||||.|||||||||
  Fly    25 KLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIM 89

Human    78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142
            ||||||:||:|||||||..||||.||||||||||||:|||.||||||||||||..||:||.|||.
  Fly    90 QQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHL 154

Human   143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 207
            .|||||||||.||||||||:||||||||||||||||||||||||||||||||||:||||:|||||
  Fly   155 RRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADI 219

Human   208 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATA 272
            |||||||:|||||||||.:|||||||||||..|||:||:|:.||..|.|||.:||||.|:.||||
  Fly   220 WSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATA 284

Human   273 TQLLQHPFVRSAKGVSILRDLINEAMDVK--------------------LKRQES--QQREVDQ- 314
            |:||:|.|:|:||..|||:.::.|...::                    |..||:  ||...|.
  Fly   285 TELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNA 349

Human   315 --------------DDEENSEEDE---------MDSGTM----VRAVGDEMGTVRVASTMTD--- 349
                          :.:::|..|.         :|.||:    :|.:.........:|..:.
  Fly   350 FMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDM 414

Human   350 ---GANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPA---KPSFLEYF--------- 399
               .:.||:|    |.|.|||||||: |.::..|.|..|: .:|.   :|.|||:|
  Fly   415 PAVDSGTMVE----LESNLGTMVINS-DSDDSTTAKNNDD-QKPRNRYRPQFLEHFDRKNAGDGR 473

Human   400 ---------------EQKEKENQ-----------------------------------INSFGKS 414
                           ||::::.|                                   ||.:|..
  Fly   474 GDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQ 538

Human   415 ---------VPGPLKNS-------------------SDWKIPQ---------------------- 429
                     :..||.|.                   ....||.
  Fly   539 QHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAY 603

Human   430 -DGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQN 486
             :|::||||..|.:||.:||..:|..||.|||::.:||.:|||||:||:.||::||||
  Fly   604 VEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQN 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK4	NP_006273.1	STKc_MST1_2	26..281	CDD:132943	207/254 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..332		10/58 (17%)
		SARAH_MST1	432..480	CDD:439181	24/47 (51%)
hpo	NP_611427.1	STKc_MST1_2	38..293	CDD:132943	207/254 (81%)
		SARAH_Hpo	606..661	CDD:439183	29/54 (54%)