Protein Alignment STK4 and hep

DIOPT Version :10

• Sequence 1: NP_006273.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Alignment Length: 478
• Identity: 119/478 - (24%)
• Similarity: 207/478 - (43%)
• Gaps: 86/478 - (17%)

Human    26 PEEVFDV--LEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE---IIKEIS-IMQQCDSPH 84
            |.::.|:  |..||.|:.|:|.|.:|..:..|:|:||:....:.:|   |:.::. :::..|..:
  Fly   191 PTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKY 255

Human    85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYL---HFMRKI 146
            :||..|.:.::.|:||.||.... ....:::|..|.:.|..:..:..:|:..|.||   |.:  |
  Fly   256 IVKCLGCFVRDPDVWICMELMSM-CFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGV--I 317

Human   147 HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI--QEIGYNCVADIWS 209
            |||:|..|||::..|:.||.|||::|:|.|:.|...:. |...:||||.|  ::..|:..||:||
  Fly   318 HRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSA-GCAAYMAPERIDPKKPKYDIRADVWS 381

Human   210 LGITAIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPE--LWSDNFTDFVKQCLVKSPEQRAT 271
            ||||.:|:|..:.||...: ....:..:..:.||.....|  .:|..|.|||.:||.|:.:.|..
  Fly   382 LGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPK 446

Human   272 ATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
            ..:||..||:|..:...:  |:.|....:|..|..:           |.:.....:.....|:|.
  Fly   447 YPELLAQPFIRIYESAKV--DVPNWFQSIKDNRLRA-----------NGDPTLQRATATGSAIGS 498

Human   337 EMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAK-PSF----L 396
            ..|::..:.:.:.|.........|...|..|               ...:|::|.: ||:    .
  Fly   499 GAGSLAGSGSGSAGGAVKYGRATTYAGQSPT---------------NPQKTIKPTQIPSYQQQQS 548

Human   397 EYFEQKEKE----------NQINSFGKS---------------VPGPLKNSSDWKIPQDGDYEFL 436
            ::|.|...:          ...|.||.|               ..|...::|....|..|
  Fly   549 QFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAG----- 608

Human   437 KSWTVEDLQKRLLALDPMMEQEI 459
                :.|| .||....|.|::::
  Fly   609 ----IGDL-NRLYRKSPFMQRKL 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK4	NP_006273.1	STKc_MST1_2	26..281	CDD:132943	85/268 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..332		2/28 (7%)
		SARAH_MST1	432..480	CDD:439181	6/28 (21%)
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	90/290 (31%)