Protein Alignment STK4 and nak1

DIOPT Version :10

• Sequence 1: NP_006273.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 487
• Species: Homo sapiens
• Sequence 2: NP_596023.1
• Gene: nak1 / 2539963
• PomBaseID: SPBC17F3.02
• Length: 652
• Species: Schizosaccharomyces pombe
• Alignment Length: 511
• Identity: 160/511 - (31%)
• Similarity: 253/511 - (49%)
• Gaps: 104/511 - (20%)

Human    19 EDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD---LQEIIKEISI---M 77
            |::....|   :..||.:|.||||:||:.|...|.:.||||.:.:::|   :.:|.||:::   :
pombe     2 ENNTASSP---YTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSEL 63

Human    78 QQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142
            :|.|..:::||:|||...|:|||:|:||..|||..:  :....::|..|:.||:.||:.|:::|.
pombe    64 KQSDVENIIKYHGSYLVGTNLWIIMDYCHGGSVRTL--MEAGPISEPCISLILRETLQALKFIHH 126

Human   143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCV 204
            ...|||||||.|||::..|:.||.|||||.:|.....||.|.||||:|||||||   ||  ||.:
pombe   127 AGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQE--YNVM 189

Human   205 ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFT----DFVKQCLVKS 265
            ||||||||||.|:|.|.||:|...|.||:::|....||..      :.||:    :|:..||...
pombe   190 ADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRL------NGNFSALLKEFIASCLQDV 248

Human   266 PEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQRE--------VDQDDEENSEE 322
            |::|..:::||:..|::....:|     |:|..:| :||.::.|..        :.::.::.|:.
pombe   249 PQRRLDSSELLKSKFIKQYSRMS-----ISELTNV-VKRYDTWQAAGGIPQTLLLGEEADDGSDP 307

Human   323 DEMDSGTMVRAVGDEMGTVR-------------------------VASTMTDGANTMIE------ 356
            |:..|.|.....|.|.||::                         |..|:...::|:.|
pombe   308 DQETSDTAASDDGWEFGTIKQGQSNVSSITGTSTSTTTAATSSTTVTGTVIPKSSTVHEPPSSND 372

Human   357 -------------HDDTLPSQLGTMVINAE---DEEEEG-------TMKRRDETMQPAKPSFLEY 398
                         .||..||       |||   .|:.:|       .:...|.:...:|.|.::.
pombe   373 SHPLLQLFKDSKISDDDSPS-------NAEGASTEDSKGEVSYSQIELPSLDSSNLSSKKSTIQS 430

Human   399 FEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPM 454
            ...|:.|:.....|::.... |.|||..|.:.......:..|  .|.||.:::.||
pombe   431 KHTKQAEDYDLFVGRTRSNS-KTSSDQSIKRPLPRVVQRQKT--SLGKRGISMSPM 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK4	NP_006273.1	STKc_MST1_2	26..281	CDD:132943	113/267 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..332		7/36 (19%)
		SARAH_MST1	432..480	CDD:439181	6/23 (26%)
nak1	NP_596023.1	Protein Kinases, catalytic domain	8..282	CDD:473864	119/292 (41%)