Protein Alignment STK3 and hep

DIOPT Version :10

• Sequence 1: XP_016869245.1
• Gene: STK3 / 6788
• HGNCID: 11406
• Length: 580
• Species: Homo sapiens
• Sequence 2: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 115/411 - (27%)
• Similarity: 194/411 - (47%)
• Gaps: 45/411 - (10%)

Human    90 NKQDSKLKKLSED------SLTKQPEEVFDV--LEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE 146
            ::.|.|||.:.|.      :..:.|.::.|:  |..||.|:.|:|.|.:|..|..::|:||:...
  Fly   167 SETDMKLKIIMEQTGKLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRT 231

Human   147 SDLQE---IIKEIS-IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE 207
            .:.:|   |:.::. :::..|..|:||..|.:.::.|:||.||.... ....:::|..|.:.|..
  Fly   232 GNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSM-CFDKLLKLSKKPVPEQI 295

Human   208 IATILKSTLKGLEYL---HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGT 269
            :..:..:|:..|.||   |.:  ||||:|..|||::..|:.||.|||::|:|.|:.|...:. |.
  Fly   296 LGKVTVATVNALSYLKDKHGV--IHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSA-GC 357

Human   270 PFWMAPEVI--QEIGYNCVADIWSLGITSIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPE- 330
            ..:||||.|  ::..|:..||:||||||.:|:|..:.||...: ....:..:..:.||.....|
  Fly   358 AAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEG 422

Human   331 -LWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQREL 394
             .:|..|.|||.|||.||.:.|....:||..|||:..:...:  |:......||..|
  Fly   423 YNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKV--DVPNWFQSIKDNR-------- 477

Human   395 EEEEENSDEDELDSHTMVKTSVES-VGTMRATSTMSEG-------AQTMIEHNSTMLESDLGTMV 451
              ...|.| ..|...|...:::.| .|::..:.:.|.|       |.|....:.|..:..:....
  Fly   478 --LRANGD-PTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQ 539

Human   452 INSEDEEEEDGTMKRNATSPQ 472
            |.|..:::....|:.....||
  Fly   540 IPSYQQQQSQFFMQSATQLPQ 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STK3	XP_016869245.1	STKc_MST1_2	108..363	CDD:132943	88/268 (33%)
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	93/300 (31%)