DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEK4 and ARK1

DIOPT Version :9

Sequence 1:	XP_016862574.1	Gene:	NEK4 / 6787	HGNCID:	11399	Length:	870	Species:	Homo sapiens
Sequence 2:	NP_014378.1	Gene:	ARK1 / 855711	SGDID:	S000004965	Length:	638	Species:	Saccharomyces cerevisiae

Alignment Length:	580	Identity:	126/580 - (21%)
Similarity:	228/580 - (39%)	Gaps:	123/580 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    34 IKKLNLRNASSRERRAAEQEAQLLSQLKHPN-IVTY------KESWEGGDGLLYIVMGFCEGGDL 91
            :|::.:.:..|.....||.:|..|  ||:.. :|:|      |.....|...::::|.:||.|.|
Yeast    55 LKRVIVPDKPSLNTLRAEVDAMRL--LKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGL 117

Human    92 YRKLKEQKGQLLPENQVVEWFVQIAMALQYLH--EKHILHRDLKTQNVFLTRTNIIKVGDL---- 150
            ...:..:....|.|.::::...|:...:..:|  :..::|||:|.:||.::..|..|:.|.
Yeast   118 IDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVC 182

Human   151 GIARVLENHCDMA--------STLIGTPYYMSPEL---FSNKPYNYKSDVWALGCCVYEMATLKH 204
            ||.|...|..:::        :|   |..|.|||:   |...|.:.|||:||||..:|::.....
Yeast   183 GIIRPPRNSQELSYVQQDILKNT---TAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTT 244

Human   205 AF-NAKDMNSLVYRIIEGKLP-PMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQI-- 265
            .| ...|:     .|:.||.. |:..:||.:|..|||.:|.:.|..||:|..:|::..|.:.:
Yeast   245 PFEKGGDL-----AILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPC 304

Human   266 -----------SFFLEATKI---------------KTSKNNIKNGDSQ---------------SK 289
                       |..|..|::               .|.:|.:.|...|               .|
Yeast   305 PINDIQVVQAPSSHLNLTELHQLSATQNILSLNSPTTMENTMPNATFQISMADNTTTAQMHPNRK 369

Human   290 P--------FATVVSG------EAESNHEVIHP---QPLSSEGSQTYIMGEGKCLSQEKPRASGL 337
            |        |:....|      ::::.:..:.|   :||:|..|...        ::.|..::..
Yeast   370 PSQIAYDASFSNSAKGSQPLFDKSQNMYHALDPPLVEPLASSVSNND--------NELKANSATK 426

Human   338 LKSPASLKAHTCKQDLSNTTELATISSVNIDILP-----AKGRDSVSDGFVQE-NQPRYLDASNE 396
            ||.....:|||.:|:.|....|.       :|:|     :...|....|.|.| .:.|.|.:.:.
Yeast   427 LKQAIVSEAHTFRQNNSIDFPLQ-------NIIPQYEDSSSSSDESYSGDVDELKKTRSLGSYST 484

Human   397 LGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALS 461
            .|.|.....|:|.:    |.||....:..|. |:.:....:|.|.|.......:....|.:....
Yeast   485 RGNIKKNQSVKESL----TSSSLPGTSFTPT-STKVNLKHENSPFKSTFVNTIDNSKDDLNKPSY 544

Human   462 PKLECSGTILAHS-NLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPD 520
            ..|:.|...|.:| ..|::...:|...:.....::.|..|.:.::....:::..|.|..|
Yeast   545 EDLDVSKQNLKNSIQQRMIDKLNSSEESFNARKMSKVKLHEKGEIDKPTMLKSSGPISKD 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK4	XP_016862574.1	None
ARK1	NP_014378.1	STKc_NAK_like	18..301	CDD:270939	69/255 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910