Protein Alignment NEK4 and PRK1

DIOPT Version :9

• Sequence 1: XP_016862574.1
• Gene: NEK4 / 6787
• HGNCID: 11399
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_012171.1
• Gene: PRK1 / 854713
• SGDID: S000001357
• Length: 810
• Species: Saccharomyces cerevisiae
• Alignment Length: 834
• Identity: 171/834 - (20%)
• Similarity: 310/834 - (37%)
• Gaps: 210/834 - (25%)

Human    48 RAAEQEAQLLSQLKHPNIVTYKESW--EGGDGLLY---IVMGFCEGGDLYRKLKEQKGQLLPENQ 107
            ||.....:||...||  :|:|.:|.  ...:|:.|   ::|.|||.|.|...:..:....|.|::
Yeast    70 RAEVDAMKLLRNNKH--VVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTRLQNRLQESE 132

Human   108 VVEWFVQIAMALQYLH--EKHILHRDLKTQNVFLTRTNIIKVGDLG-IARVLE-----------N 158
            ::|...|....:..:|  :..::|||:|.:||.::...:.||.|.| ::.|:.           .
Yeast   133 ILEIMSQTVQGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQ 197

Human   159 HCDMASTLIGTPYYMSPE---LFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIE 220
            |..:.:|   |..|.|||   |:...|.:.|||:||||..:|::......|.......:::  ..
Yeast   198 HDILTNT---TAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILH--AR 257

Human   221 GKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGD 285
            .:.|..|: ||..|..|||.||.:.|.:||::..:|.            |.::::.....|:|
Yeast   258 YQYPSFPQ-YSDRLKNLIRLMLMEAPSQRPNICQVLE------------EVSRLQNKPCPIRN-- 307

Human   286 SQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCK 350
                 |..:.:....:|.:      |:.|.|.|..:...|.:..:..::   :..|.::...|
Yeast   308 -----FYLLRAMNQNANTQ------LAGEPSSTTYVPTQKFIPVQSLQS---INQPPNMMPVT-- 356

Human   351 QDLSNTTELATIS-SVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDN 414
             .:|.|..|.|.. |:|                  :|....:.|...| .:.|.|.:...:::
Yeast   357 -HVSTTPNLGTFPISIN------------------DNNKTEVTAHAGL-QVGSHSNLTSPLMK-- 399

Human   415 TKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSP-------KLEC------ 466
            |||....:....::..::...:|::..|.::.....|:.....|:|:|       ::..
Yeast   400 TKSVPLSDEFASLYYKELHPFQKSQTFKSVESFQSPQRKSMPPLSLTPVNNDIFDRVSAINRPNN 464

Human   467 -----SGTI--LAHSNLRLLG--SSDSPASASRVAGITGVCHHAQDQVAGECIIEK-QGRIHPDL 521
                 :.||  :|..||:|..  :|.|.:|...:|        |.|.:.|..|:.. ..::...:
Yeast   465 YVDSETQTIDNMAVPNLKLSPTITSKSLSSTKEIA--------APDNINGSKIVRSLSSKLKKVI 521

Human   522 QPHNSGSEPSLSRQR------------------------RQKRREQTEHRGEKRQVRRDLFAFQE 562
            ...:.|:.|..|||.                        |....:.....|......|.|.:...
Yeast   522 TGESRGNSPIKSRQNTGDSIRSAFGKLRHGFTGNSVNNSRSASFDNNNVNGNGNNTNRRLVSSST 586

Human   563 SP-PRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQE 626
            |. |:|        ..|....::..:|||      :...||...|...|  ....||...:....
Yeast   587 SSFPKF--------NSDTKRKEESDKNQR------LEKRRSMPPSILSD--FDQHERNNSRTGSR 635

Human   627 EMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQ-----IHCLSEDELSSSTS 686
            :...|...|:|...|.....||    ..:|.   :.:.::.||:|:     :|.|.:   ||...
Yeast   636 DYYRSHSPVKKTQASAKTTSKP----TLIPD---NGNVNINQEKKESIQRRVHNLLK---SSDDP 690

Human   687 STDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLI---- 747
            .|.||...||:          ...:.|:|   .::.|...:   .|::|.|..:..:|.::
Yeast   691 VTYKSASGYGK----------YTDIGTET---SNRHSSVRI---TPITEEKFKKTLKDGVLDIKT 739

Human   748 -LHGK--------------VAEEAEEI-HFKELPSAIMP----GSEKIRRLVEV 781
             .:||              :..|.::| :|..|.|..:|    .||....:|:|
Yeast   740 KSNGKDKSRPPRPPPKPLHLRTEIQKIRNFSRLQSKKLPIERISSEATETIVDV 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK4	XP_016862574.1	None
PRK1	NP_012171.1	STKc_NAK_like	18..300	CDD:270939	66/249 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910