Protein Alignment NEK4 and HRK1

DIOPT Version :9

• Sequence 1: XP_016862574.1
• Gene: NEK4 / 6787
• HGNCID: 11399
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_014910.1
• Gene: HRK1 / 854441
• SGDID: S000005793
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 642
• Identity: 126/642 - (19%)
• Similarity: 230/642 - (35%)
• Gaps: 194/642 - (30%)

Human    10 RVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQ---EAQLLSQLKHPNIV-TYKE 70
            :::|.|:.|.|.::....||..:.:|:...|..:...:..|::   |..:.|.|.|||:: |...
Yeast   219 KLLGSGAGGSVKVLVRPTDGATFAVKEFRPRKPNESVKEYAKKCTAEFCIGSTLHHPNVIETVDV 283

Human    71 SWEGGDGLLYIVMGFCEGGDLYRKL---KEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDL 132
            ..:......|.||.:|. .|.:..:   |..:|::   |..::   |:...::|||...:.||||
Yeast   284 FSDSKQNKYYEVMEYCP-IDFFAVVMTGKMSRGEI---NCCLK---QLTEGVKYLHSMGLAHRDL 341

Human   133 KTQNVFLTRTNIIKVGDLGIARV----LENHCDMASTLIGTPYYMSPELF-SNKPYNYKS-DVWA 191
            |..|..:|...|:|:.|.|.|.|    .|:...||..::|:..|::||:. |.|.|:.:. |:|:
Yeast   342 KLDNCVMTSQGILKLIDFGSAVVFRYPFEDGVTMAHGIVGSDPYLAPEVITSTKSYDPQCVDIWS 406

Human   192 LG---CCVYEMATLKH----AFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIR---TMLSKRP 246
            :|   ||:    .||.    |....|.|..:|        .||.|...:..|..|   .:|.:|.
Yeast   407 IGIIYCCM----VLKRFPWKAPRDSDDNFRLY--------CMPDDIEHDYVESARHHEELLKERK 459

Human   247 EERP-----SVRSILRQPYIKRQISFFLEATKIKTSKNNIKN------GDSQSKPFATVVSGEAE 300
            |:|.     |..|.:.|.....:       :.:||.:|.:.|      |.|.:||  .:|..|.|
Yeast   460 EKRQRFLNHSDCSAINQQQPAHE-------SNLKTVQNQVPNTPASIQGKSDNKP--DIVEEETE 515

Human   301 SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSV 365
            .|                                               |:|.||..:.:|
Yeast   516 EN-----------------------------------------------KEDDSNNDKEST---- 529

Human   366 NIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSS 430
                 |...::|..|..:.:|:.:                        :|..||.|:.:.....:
Yeast   530 -----PDNDKESTIDIKISKNENK------------------------STVVSANPKKVDADADA 565

Human   431 DI-VTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGI 494
            |. ..|:.|..|.                 .....:|:.....::|......||..|..
Yeast   566 DCDANGDSNGRVD-----------------CKANSDCNDKTDCNANNDCSNESDCNAKV------ 607

Human   495 TGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFA 559
                         :..:......:||:.|.|:..:....:|::|::::|.:.:....|.:.
Yeast   608 -------------DTNVNTAANANPDMVPQNNPQQQQQQQQQQQQQQQQQQQQHHHHQHQN---- 655

Human   560 FQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSAR 616
             |:.      :|.|... :.:|.|....:.::::.|..   |...:.....||:.:|
Yeast   656 -QDK------AHSIASD-NKSSQQHRGPHHKKIIHGPY---RLLRLLPHASRPIMSR 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK4	XP_016862574.1	None
HRK1	NP_014910.1	PKc_like	221..435	CDD:419665	62/232 (27%)
		MSCRAMM_ClfB	<469..673	CDD:411414	50/340 (15%)
		PKc_like	<677..721	CDD:419665	5/28 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910