Protein Alignment NEK4 and SSK22

DIOPT Version :9

• Sequence 1: XP_016862574.1
• Gene: NEK4 / 6787
• HGNCID: 11399
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_009998.2
• Gene: SSK22 / 850436
• SGDID: S000000669
• Length: 1331
• Species: Saccharomyces cerevisiae
• Alignment Length: 285
• Identity: 81/285 - (28%)
• Similarity: 139/285 - (48%)
• Gaps: 35/285 - (12%)

Human    12 VGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRER--RAAEQEAQLLSQLKHPNIVTYKESWEG 74
            :|.|::|:|....:..:|:...:|::.:.:.::.::  ...::|..:|..|.|||||.| ...|.
Yeast  1040 IGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQY-YGVEV 1103

Human    75 GDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL 139
            ....:.|.|.:||||.|...|  ..|::..|.....:..::...|.|||:..::|||:|.:|:.|
Yeast  1104 HRDKVNIFMEYCEGGSLASLL--DHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILL 1166

Human   140 TRTNIIKVGDLGIARVLEN----------------HCDMASTLIGTPYYMSPELFSNKPYNYK-- 186
            ....|||..|.|.||.:..                .....:.::|||.||:||..|......|
Yeast  1167 DFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLG 1231

Human   187 -SDVWALGCCVYEMATLKHAFNAKDMN-SLVYRIIEGKLPPMP-RDYSPELAELIRTMLSKRPEE 248
             .|||||||.|.||||.:..::..|.. :::|.:..|::|.:| ||   |:....|..|.:...:
Yeast  1232 ADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRD---EMTAAGRAFLERCLVQ 1293

Human   249 RPSVRS----ILRQPYI--KRQISF 267
            .|::|:    :|..|::  .|:|:|
Yeast  1294 DPTMRATAVELLIDPWMIQIREIAF 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK4	XP_016862574.1	None
SSK22	NP_009998.2	STKc_MEKK4	1033..1309	CDD:270796	77/274 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910